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Henoch-Schonlein purpura in mesothelioma.

Joshi S, Pillai S, Chakera A, Lee YC - Respirol Case Rep (2014)

Bottom Line: When adults are affected, malignancy can be associated.He presented with episodes of dizziness and subsequently developed non-palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment.He was treated with high-dose oral steroids with resolution of the skin and renal manifestations of the disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital Perth, Western Australia, Australia.

ABSTRACT
Henoch-Schonlein purpura (HSP) is primarily a childhood immunoglobulin A (IgA)-mediated illness. When adults are affected, malignancy can be associated. We present a rare case of HSP in a 75-year-old man with malignant pleural mesothelioma. He presented with episodes of dizziness and subsequently developed non-palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment. HSP was diagnosed based on clinical and histological findings on biopsy specimens from the skin and kidney that showed a leukocytoclastic vasculitis and mesangioproliferative glomerulonephritis with IgA deposits, respectively. He was treated with high-dose oral steroids with resolution of the skin and renal manifestations of the disease. HSP is rare in adults but has been linked to cancers. This is the first report of HSP in a patient with known malignant pleural mesothelioma.

No MeSH data available.


Related in: MedlinePlus

Skin biopsy (×20): perivascular inflammatory infiltrate comprising neutrophils, lymphocytes, and histiocytes with moderate amount of leukocytoclastic debris.
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fig01: Skin biopsy (×20): perivascular inflammatory infiltrate comprising neutrophils, lymphocytes, and histiocytes with moderate amount of leukocytoclastic debris.

Mentions: A biopsy of his skin rash (Fig. 1) revealed perivascular inflammation with leukocytoclastic debris. His renal biopsy showed mesangio-proliferative glomerulonephritis and, on immunofluorescence studies, strong granular IgA deposition in the mesangium of all glomeruli associated with moderate C3 and fibrinogen deposition (Fig. 2). This confirmed an IgA nephropathy, and a clinical diagnosis of HSP was made.


Henoch-Schonlein purpura in mesothelioma.

Joshi S, Pillai S, Chakera A, Lee YC - Respirol Case Rep (2014)

Skin biopsy (×20): perivascular inflammatory infiltrate comprising neutrophils, lymphocytes, and histiocytes with moderate amount of leukocytoclastic debris.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263495&req=5

fig01: Skin biopsy (×20): perivascular inflammatory infiltrate comprising neutrophils, lymphocytes, and histiocytes with moderate amount of leukocytoclastic debris.
Mentions: A biopsy of his skin rash (Fig. 1) revealed perivascular inflammation with leukocytoclastic debris. His renal biopsy showed mesangio-proliferative glomerulonephritis and, on immunofluorescence studies, strong granular IgA deposition in the mesangium of all glomeruli associated with moderate C3 and fibrinogen deposition (Fig. 2). This confirmed an IgA nephropathy, and a clinical diagnosis of HSP was made.

Bottom Line: When adults are affected, malignancy can be associated.He presented with episodes of dizziness and subsequently developed non-palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment.He was treated with high-dose oral steroids with resolution of the skin and renal manifestations of the disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital Perth, Western Australia, Australia.

ABSTRACT
Henoch-Schonlein purpura (HSP) is primarily a childhood immunoglobulin A (IgA)-mediated illness. When adults are affected, malignancy can be associated. We present a rare case of HSP in a 75-year-old man with malignant pleural mesothelioma. He presented with episodes of dizziness and subsequently developed non-palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment. HSP was diagnosed based on clinical and histological findings on biopsy specimens from the skin and kidney that showed a leukocytoclastic vasculitis and mesangioproliferative glomerulonephritis with IgA deposits, respectively. He was treated with high-dose oral steroids with resolution of the skin and renal manifestations of the disease. HSP is rare in adults but has been linked to cancers. This is the first report of HSP in a patient with known malignant pleural mesothelioma.

No MeSH data available.


Related in: MedlinePlus