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Discordance between clinical, physiological, and radiological measures in cystic fibrosis.

Barry PJ, Horsley AR - Respirol Case Rep (2014)

Bottom Line: As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF.Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF.Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

View Article: PubMed Central - PubMed

Affiliation: Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester Wythenshawe, UK.

ABSTRACT
There are several methods available to the clinician to assess severity of lung disease in cystic fibrosis (CF). Here we present a case where several of these modalities appeared to be discordant. As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF. Spirometry may be insensitive to significant changes that are apparent both clinically and radiologically, but remains an important marker of short-term change, response to intervention, and prognosis. Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF. Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

No MeSH data available.


Related in: MedlinePlus

(A) Representative images from a computed tomography (CT) thorax of the cystic fibrosis patient, revealing significant bronchiectatic changes. (B) Expiratory images from CT thorax, revealing a mosaic pattern consistent with air trapping.
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fig02: (A) Representative images from a computed tomography (CT) thorax of the cystic fibrosis patient, revealing significant bronchiectatic changes. (B) Expiratory images from CT thorax, revealing a mosaic pattern consistent with air trapping.

Mentions: High-resolution computed tomography (CT) revealed extensive bilateral bronchiectasis, with slight upper lobe predominance, and severe patchy air trapping indicative of widespread small airways obstruction (see Fig. 2A and B). The degree of bronchiectasis was in excess of what was anticipated from the spirometric measurements.


Discordance between clinical, physiological, and radiological measures in cystic fibrosis.

Barry PJ, Horsley AR - Respirol Case Rep (2014)

(A) Representative images from a computed tomography (CT) thorax of the cystic fibrosis patient, revealing significant bronchiectatic changes. (B) Expiratory images from CT thorax, revealing a mosaic pattern consistent with air trapping.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263492&req=5

fig02: (A) Representative images from a computed tomography (CT) thorax of the cystic fibrosis patient, revealing significant bronchiectatic changes. (B) Expiratory images from CT thorax, revealing a mosaic pattern consistent with air trapping.
Mentions: High-resolution computed tomography (CT) revealed extensive bilateral bronchiectasis, with slight upper lobe predominance, and severe patchy air trapping indicative of widespread small airways obstruction (see Fig. 2A and B). The degree of bronchiectasis was in excess of what was anticipated from the spirometric measurements.

Bottom Line: As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF.Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF.Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

View Article: PubMed Central - PubMed

Affiliation: Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester Wythenshawe, UK.

ABSTRACT
There are several methods available to the clinician to assess severity of lung disease in cystic fibrosis (CF). Here we present a case where several of these modalities appeared to be discordant. As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF. Spirometry may be insensitive to significant changes that are apparent both clinically and radiologically, but remains an important marker of short-term change, response to intervention, and prognosis. Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF. Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

No MeSH data available.


Related in: MedlinePlus