Limits...
Discordance between clinical, physiological, and radiological measures in cystic fibrosis.

Barry PJ, Horsley AR - Respirol Case Rep (2014)

Bottom Line: As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF.Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF.Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

View Article: PubMed Central - PubMed

Affiliation: Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester Wythenshawe, UK.

ABSTRACT
There are several methods available to the clinician to assess severity of lung disease in cystic fibrosis (CF). Here we present a case where several of these modalities appeared to be discordant. As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF. Spirometry may be insensitive to significant changes that are apparent both clinically and radiologically, but remains an important marker of short-term change, response to intervention, and prognosis. Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF. Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

No MeSH data available.


Related in: MedlinePlus

Flow volume loop revealing expiratory flow limitation on forced expiratory maneuver and a tidal breath. Normative curve is shown in green.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4263492&req=5

fig01: Flow volume loop revealing expiratory flow limitation on forced expiratory maneuver and a tidal breath. Normative curve is shown in green.

Mentions: Full lung function measures were notable for well-preserved FEV1 and forced vital capacity (FVC) (86% and 98% predicted respectively). His flow volume loop however revealed marked scalloping of the expiratory limb (see Fig. 1), without significant bronchodilator reversibility. Gas diffusion coefficient was normal, but a 1 liter (L) discrepancy was noted in total lung capacity (6.58 L vs. 7.50 L, 122% vs. 139% predicted) and functional residual capacity when comparing plethysmography to dilutional methods, suggesting both hyperinflation and air trapping.


Discordance between clinical, physiological, and radiological measures in cystic fibrosis.

Barry PJ, Horsley AR - Respirol Case Rep (2014)

Flow volume loop revealing expiratory flow limitation on forced expiratory maneuver and a tidal breath. Normative curve is shown in green.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263492&req=5

fig01: Flow volume loop revealing expiratory flow limitation on forced expiratory maneuver and a tidal breath. Normative curve is shown in green.
Mentions: Full lung function measures were notable for well-preserved FEV1 and forced vital capacity (FVC) (86% and 98% predicted respectively). His flow volume loop however revealed marked scalloping of the expiratory limb (see Fig. 1), without significant bronchodilator reversibility. Gas diffusion coefficient was normal, but a 1 liter (L) discrepancy was noted in total lung capacity (6.58 L vs. 7.50 L, 122% vs. 139% predicted) and functional residual capacity when comparing plethysmography to dilutional methods, suggesting both hyperinflation and air trapping.

Bottom Line: As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF.Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF.Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

View Article: PubMed Central - PubMed

Affiliation: Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester Wythenshawe, UK.

ABSTRACT
There are several methods available to the clinician to assess severity of lung disease in cystic fibrosis (CF). Here we present a case where several of these modalities appeared to be discordant. As in this case, many assessments of respiratory status may be necessary to fully evaluate patients with CF. Spirometry may be insensitive to significant changes that are apparent both clinically and radiologically, but remains an important marker of short-term change, response to intervention, and prognosis. Chest computed tomography can provide valuable detailed information on the health of the lungs and is more sensitive than spirometry to the changes seen in CF. Longitudinal studies of subjects with disproportionately severe radiological changes may be important to assess whether they are more at risk of precipitous declines in pulmonary function.

No MeSH data available.


Related in: MedlinePlus