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Genome-wide Analysis of Mycoplasma hominis for the Identification of Putative Therapeutic Targets.

Parvege MM, Rahman M, Hossain MS - Drug Target Insights (2014)

Bottom Line: Our study also identified 179 essential proteins, including 59 proteins having no similarity with human proteins.Further filtering by molecular weight, subcellular localization, functional analysis, and protein network interaction, we identified 57 putative candidates for which new drugs can be developed.Druggability analysis for each of the identified targets has prioritized 16 proteins as suitable for potential drug development.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka, Bangladesh.

ABSTRACT
Ever increasing propensity of antibiotic resistance among pathogenic bacteria raises the demand for the development of novel therapeutic agents to control this grave problem. Advances in the field of bioinformatics, genomics, and proteomics have greatly facilitated the discovery of alternative drugs by swift identification of new drug targets. In the present study, we employed comparative genomics and metabolic pathway analysis with an aim of identifying therapeutic targets in Mycoplasma hominis. Our study has revealed 40 annotated metabolic pathways, including five unique pathways of M. hominis. Our study also identified 179 essential proteins, including 59 proteins having no similarity with human proteins. Further filtering by molecular weight, subcellular localization, functional analysis, and protein network interaction, we identified 57 putative candidates for which new drugs can be developed. Druggability analysis for each of the identified targets has prioritized 16 proteins as suitable for potential drug development.

No MeSH data available.


Related in: MedlinePlus

Comparison of M. hominis genome against DEG. The height of the bars indicates the number of hits on other genomes.
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Related In: Results  -  Collection


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f2-dti-8-2014-051: Comparison of M. hominis genome against DEG. The height of the bars indicates the number of hits on other genomes.

Mentions: Proteins that are required by pathogenic microorganisms to survive are called essential proteins. Essential proteins are prime targets for drugs and vaccine development. To identify the essential proteins, 198 proteins of common and unique pathways were compared against the DEG database. Out of 198 input proteins, 179 proteins were found to be essential for the pathogen. The distribution of the 179 identified essential proteins in each of the 22 bacteria of DEG is presented in Figure 2.


Genome-wide Analysis of Mycoplasma hominis for the Identification of Putative Therapeutic Targets.

Parvege MM, Rahman M, Hossain MS - Drug Target Insights (2014)

Comparison of M. hominis genome against DEG. The height of the bars indicates the number of hits on other genomes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4263438&req=5

f2-dti-8-2014-051: Comparison of M. hominis genome against DEG. The height of the bars indicates the number of hits on other genomes.
Mentions: Proteins that are required by pathogenic microorganisms to survive are called essential proteins. Essential proteins are prime targets for drugs and vaccine development. To identify the essential proteins, 198 proteins of common and unique pathways were compared against the DEG database. Out of 198 input proteins, 179 proteins were found to be essential for the pathogen. The distribution of the 179 identified essential proteins in each of the 22 bacteria of DEG is presented in Figure 2.

Bottom Line: Our study also identified 179 essential proteins, including 59 proteins having no similarity with human proteins.Further filtering by molecular weight, subcellular localization, functional analysis, and protein network interaction, we identified 57 putative candidates for which new drugs can be developed.Druggability analysis for each of the identified targets has prioritized 16 proteins as suitable for potential drug development.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka, Bangladesh.

ABSTRACT
Ever increasing propensity of antibiotic resistance among pathogenic bacteria raises the demand for the development of novel therapeutic agents to control this grave problem. Advances in the field of bioinformatics, genomics, and proteomics have greatly facilitated the discovery of alternative drugs by swift identification of new drug targets. In the present study, we employed comparative genomics and metabolic pathway analysis with an aim of identifying therapeutic targets in Mycoplasma hominis. Our study has revealed 40 annotated metabolic pathways, including five unique pathways of M. hominis. Our study also identified 179 essential proteins, including 59 proteins having no similarity with human proteins. Further filtering by molecular weight, subcellular localization, functional analysis, and protein network interaction, we identified 57 putative candidates for which new drugs can be developed. Druggability analysis for each of the identified targets has prioritized 16 proteins as suitable for potential drug development.

No MeSH data available.


Related in: MedlinePlus