Pretreatment prediction of the outcome of response-guided peginterferon-α and ribavirin therapy for chronic hepatitis C.
Bottom Line: Our in vitro study revealed that the numbers of (TA) dinucleotide repeats [(TA)n] of rs72258881, which is located in the promoter region of IL28B gene, might regulate IL28B transcription.We aimed to evaluate the usefulness of these host factors for predicting virological outcomes of this therapy in response-guided clinical settings.Multivariate logistic regression analysis revealed that rs8099917 non-TT genotype (P < 0.001), shorter (TA)n (P = 0.011), mutation of amino acid 70 in the virus core region (P = 0.029), and lower levels of serum albumin (P = 0.036) were independently associated with non-virological response.
Affiliation: The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan.Show MeSH
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Mentions: Intent-to-treat analysis of the entire cohort indicated SVR, TVR, and NVR rates of 49.3%, 12.6%, and 32.1%, respectively. As shown in Figure 3a, serum HCV RNA disappeared significantly earlier in patients with TT genotype than in those with either of the TG or GG genotype. Assessment of the usefulness of the rs8099917 non-TT genotype to predict NVR among 202 patients in whom the final virological outcome could be determined indicate a sensitivity of 63.8% (44/[44 + 25]); specificity of 88.0% (117/[117 + 16]); positive predictive value of 73.3% (44/[44 + 16]); negative predictive value of 82.4% (117/[25 + 117]), and an accuracy of 79.7% ([44 + 117]/202).
Affiliation: The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan.