Pretreatment prediction of the outcome of response-guided peginterferon-α and ribavirin therapy for chronic hepatitis C.
Bottom Line: Our in vitro study revealed that the numbers of (TA) dinucleotide repeats [(TA)n] of rs72258881, which is located in the promoter region of IL28B gene, might regulate IL28B transcription.We aimed to evaluate the usefulness of these host factors for predicting virological outcomes of this therapy in response-guided clinical settings.Multivariate logistic regression analysis revealed that rs8099917 non-TT genotype (P < 0.001), shorter (TA)n (P = 0.011), mutation of amino acid 70 in the virus core region (P = 0.029), and lower levels of serum albumin (P = 0.036) were independently associated with non-virological response.
Affiliation: The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan.Show MeSH
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Mentions: In this prospective study, 215 patients infected by HCV of serotype 1 or genotype 1 were eligible. The sub-genotypes of HCV were as follows: 1a (n = 2), 1b (n = 208), 1b + 2b (n = 1), and indeterminate (n = 4). By the end of November 2012, virological outcomes had been determined in 202 patients, except for 13 patients (6%) who were lost to follow-up. Whereas all of these patients were treated with P/R, 160 patients (74%) completed standard of care (SOC) treatment for at least 48 weeks, the remaining 55 patients had to withdraw from treatment owing to either serious adverse events (SAE) in 25 patients (12%), poor response in 24 patients (11%), or other unrelated causes in 6 patients (3%). The SAE or unrelated causes responsible for the termination of the treatment were described in the small inset of Figure 2.
Affiliation: The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan.