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Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis.

Sakae TM, Maurici R, Trevisol DJ, Pizzichini MM, Pizzichini E - J Bras Pneumol (2014)

Bottom Line: The independent variables were the use, dose, and duration of prednisone treatment.The pooled analysis of the pre- vs. post-treatment data revealed a significant mean reduction in sputum eosinophils (↓8.18%; 95% CI: 7.69-8.67; p < 0.001), sputum IL-5 (↓83.64 pg/mL; 95% CI: 52.45-114.83; p < 0.001), and sputum ECP (↓267.60 µg/L; 95% CI: 244.57-290.63; p < 0.0001), as well as a significant mean increase in post-bronchodilator FEV1 (↑8.09%; 95% CI: 5.35-10.83; p < 0.001).This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1.

View Article: PubMed Central - PubMed

Affiliation: Federal University of Santa Catarina, Florianópolis, Brazil.

ABSTRACT

Objective: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis.

Methods: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating parameters before and after prednisone use, including values for sputum eosinophils, sputum eosinophil cationic protein (ECP), and sputum IL-5-with or without values for post-bronchodilator FEV1-with corresponding 95% CIs or with sufficient data for calculation. The independent variables were the use, dose, and duration of prednisone treatment. The outcomes evaluated were sputum eosinophils, IL-5, and ECP, as well as post-bronchodilator FEV1.

Results: The pooled analysis of the pre- vs. post-treatment data revealed a significant mean reduction in sputum eosinophils (↓8.18%; 95% CI: 7.69-8.67; p < 0.001), sputum IL-5 (↓83.64 pg/mL; 95% CI: 52.45-114.83; p < 0.001), and sputum ECP (↓267.60 µg/L; 95% CI: 244.57-290.63; p < 0.0001), as well as a significant mean increase in post-bronchodilator FEV1 (↑8.09%; 95% CI: 5.35-10.83; p < 0.001).

Conclusions: In patients with moderate-to-severe eosinophilic bronchitis, treatment with prednisone caused a significant reduction in sputum eosinophil counts, as well as in the sputum levels of IL-5 and ECP. This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1.

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Reduction in sputum eosinophils after treatment with oral prednisone orprednisolone.
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f02: Reduction in sputum eosinophils after treatment with oral prednisone orprednisolone.

Mentions: The pooled analysis (n = 198) showed a six-fold mean reduction in the number ofsputum eosinophils after treatment (↓8.2%; 95% CI: 7.7-8.7; p < 0.001; Figure 2). Among studies evaluating IL-5 (inpg/mL) before and after treatment with prednisone or prednisolone (n = 114), therewas an approximately four-fold mean decrease in IL-5 levels (↓83.6; 95% CI:52.5-83.6; p < 0.001; Figure 3). Inaddition, among the studies evaluating ECP (in µg/L) in subjects receiving prednisoneor prednisolone (n = 80), the treatment resulted in a five-fold mean reduction in ECPlevels (↓267.6; 95% CI: 244.6-290.6; p < 0.001; Figure 4).


Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis.

Sakae TM, Maurici R, Trevisol DJ, Pizzichini MM, Pizzichini E - J Bras Pneumol (2014)

Reduction in sputum eosinophils after treatment with oral prednisone orprednisolone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263337&req=5

f02: Reduction in sputum eosinophils after treatment with oral prednisone orprednisolone.
Mentions: The pooled analysis (n = 198) showed a six-fold mean reduction in the number ofsputum eosinophils after treatment (↓8.2%; 95% CI: 7.7-8.7; p < 0.001; Figure 2). Among studies evaluating IL-5 (inpg/mL) before and after treatment with prednisone or prednisolone (n = 114), therewas an approximately four-fold mean decrease in IL-5 levels (↓83.6; 95% CI:52.5-83.6; p < 0.001; Figure 3). Inaddition, among the studies evaluating ECP (in µg/L) in subjects receiving prednisoneor prednisolone (n = 80), the treatment resulted in a five-fold mean reduction in ECPlevels (↓267.6; 95% CI: 244.6-290.6; p < 0.001; Figure 4).

Bottom Line: The independent variables were the use, dose, and duration of prednisone treatment.The pooled analysis of the pre- vs. post-treatment data revealed a significant mean reduction in sputum eosinophils (↓8.18%; 95% CI: 7.69-8.67; p < 0.001), sputum IL-5 (↓83.64 pg/mL; 95% CI: 52.45-114.83; p < 0.001), and sputum ECP (↓267.60 µg/L; 95% CI: 244.57-290.63; p < 0.0001), as well as a significant mean increase in post-bronchodilator FEV1 (↑8.09%; 95% CI: 5.35-10.83; p < 0.001).This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1.

View Article: PubMed Central - PubMed

Affiliation: Federal University of Santa Catarina, Florianópolis, Brazil.

ABSTRACT

Objective: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis.

Methods: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating parameters before and after prednisone use, including values for sputum eosinophils, sputum eosinophil cationic protein (ECP), and sputum IL-5-with or without values for post-bronchodilator FEV1-with corresponding 95% CIs or with sufficient data for calculation. The independent variables were the use, dose, and duration of prednisone treatment. The outcomes evaluated were sputum eosinophils, IL-5, and ECP, as well as post-bronchodilator FEV1.

Results: The pooled analysis of the pre- vs. post-treatment data revealed a significant mean reduction in sputum eosinophils (↓8.18%; 95% CI: 7.69-8.67; p < 0.001), sputum IL-5 (↓83.64 pg/mL; 95% CI: 52.45-114.83; p < 0.001), and sputum ECP (↓267.60 µg/L; 95% CI: 244.57-290.63; p < 0.0001), as well as a significant mean increase in post-bronchodilator FEV1 (↑8.09%; 95% CI: 5.35-10.83; p < 0.001).

Conclusions: In patients with moderate-to-severe eosinophilic bronchitis, treatment with prednisone caused a significant reduction in sputum eosinophil counts, as well as in the sputum levels of IL-5 and ECP. This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1.

Show MeSH
Related in: MedlinePlus