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Air stacking: effects on pulmonary function in patients with spinal muscular atrophy and in patients with congenital muscular dystrophy.

Marques TB, Neves Jde C, Portes LA, Salge JM, Zanoteli E, Reed UC - J Bras Pneumol (2014)

Bottom Line: In the patients without scoliosis, there was also a significant increase in FVC.When comparing patients with and without scoliosis, the increases in APCF and UPCF were more pronounced in those without scoliosis.Routine daily air-stacking maneuvers with a manual resuscitator appear to increase UPCF and APCF in patients with NMD, especially in those without scoliosis.

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.

ABSTRACT

Objective: Respiratory complications are the main causes of morbidity and mortality in patients with neuromuscular disease (NMD). The objectives of this study were to determine the effects that routine daily home air-stacking maneuvers have on pulmonary function in patients with spinal muscular atrophy (SMA) and in patients with congenital muscular dystrophy (CMD), as well as to identify associations between spinal deformities and the effects of the maneuvers.

Methods: Eighteen NMD patients (ten with CMD and eight with SMA) were submitted to routine daily air-stacking maneuvers at home with manual resuscitators for four to six months, undergoing pulmonary function tests before and after that period. The pulmonary function tests included measurements of FVC; PEF; maximum insufflation capacity (MIC); and assisted and unassisted peak cough flow (APCF and UPCF, respectively) with insufflations.

Results: After the use of home air-stacking maneuvers, there were improvements in the APCF and UPCF. In the patients without scoliosis, there was also a significant increase in FVC. When comparing patients with and without scoliosis, the increases in APCF and UPCF were more pronounced in those without scoliosis.

Conclusions: Routine daily air-stacking maneuvers with a manual resuscitator appear to increase UPCF and APCF in patients with NMD, especially in those without scoliosis.

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Related in: MedlinePlus

Correlation analysis of pre-training data. UPCF: unassisted peak coughflow; MIC: maximum insufflation capacity; APCF: assisted peak cough flow;?APCF-UPCF: difference between APCF and UPCF; and ?MIC-FVC: differencebetween MIC and FVC.
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f01: Correlation analysis of pre-training data. UPCF: unassisted peak coughflow; MIC: maximum insufflation capacity; APCF: assisted peak cough flow;?APCF-UPCF: difference between APCF and UPCF; and ?MIC-FVC: differencebetween MIC and FVC.

Mentions: As depicted in Figure 1, a comparison analysisof the pre-training data revealed a correlation between UPCF and FVC; between UPCFand MIC; between PEF and MIC; and between ΔAPCF-UPCF and ΔMIC-FVC (Figure 1).


Air stacking: effects on pulmonary function in patients with spinal muscular atrophy and in patients with congenital muscular dystrophy.

Marques TB, Neves Jde C, Portes LA, Salge JM, Zanoteli E, Reed UC - J Bras Pneumol (2014)

Correlation analysis of pre-training data. UPCF: unassisted peak coughflow; MIC: maximum insufflation capacity; APCF: assisted peak cough flow;?APCF-UPCF: difference between APCF and UPCF; and ?MIC-FVC: differencebetween MIC and FVC.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263334&req=5

f01: Correlation analysis of pre-training data. UPCF: unassisted peak coughflow; MIC: maximum insufflation capacity; APCF: assisted peak cough flow;?APCF-UPCF: difference between APCF and UPCF; and ?MIC-FVC: differencebetween MIC and FVC.
Mentions: As depicted in Figure 1, a comparison analysisof the pre-training data revealed a correlation between UPCF and FVC; between UPCFand MIC; between PEF and MIC; and between ΔAPCF-UPCF and ΔMIC-FVC (Figure 1).

Bottom Line: In the patients without scoliosis, there was also a significant increase in FVC.When comparing patients with and without scoliosis, the increases in APCF and UPCF were more pronounced in those without scoliosis.Routine daily air-stacking maneuvers with a manual resuscitator appear to increase UPCF and APCF in patients with NMD, especially in those without scoliosis.

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.

ABSTRACT

Objective: Respiratory complications are the main causes of morbidity and mortality in patients with neuromuscular disease (NMD). The objectives of this study were to determine the effects that routine daily home air-stacking maneuvers have on pulmonary function in patients with spinal muscular atrophy (SMA) and in patients with congenital muscular dystrophy (CMD), as well as to identify associations between spinal deformities and the effects of the maneuvers.

Methods: Eighteen NMD patients (ten with CMD and eight with SMA) were submitted to routine daily air-stacking maneuvers at home with manual resuscitators for four to six months, undergoing pulmonary function tests before and after that period. The pulmonary function tests included measurements of FVC; PEF; maximum insufflation capacity (MIC); and assisted and unassisted peak cough flow (APCF and UPCF, respectively) with insufflations.

Results: After the use of home air-stacking maneuvers, there were improvements in the APCF and UPCF. In the patients without scoliosis, there was also a significant increase in FVC. When comparing patients with and without scoliosis, the increases in APCF and UPCF were more pronounced in those without scoliosis.

Conclusions: Routine daily air-stacking maneuvers with a manual resuscitator appear to increase UPCF and APCF in patients with NMD, especially in those without scoliosis.

Show MeSH
Related in: MedlinePlus