Pericyte protection by edaravone after tissue plasminogen activator treatment in rat cerebral ischemia.
Bottom Line: The number of pericytes and the overlap with NAGO decreased with tPA but recovered with edaravone 4 days after tMCAO with proliferation.Thus, tPA treatment damaged pericytes, resulting in the detachment from astrocytes and a decrease in glial cell line-derived neurotrophic factor secretion.However, treatment with edaravone greatly improved tPA-induced damage to pericytes.
Affiliation: Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.Show MeSH
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Mentions: Figure 6 shows that fluorescent signals for GDNF (green) were partially observed surrounding the PDGFRβ-positive pericyte (red) in the peri-ischemic region of the V + V group (merged). In addition, GDNF signals obviously decreased in the V + tPA group, whereas strong overlapping yellow signals were observed in the peri-ischemic region of the E + tPA group and especially the E + V group (arrowheads).
Affiliation: Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.