Pericyte protection by edaravone after tissue plasminogen activator treatment in rat cerebral ischemia.
Bottom Line: The number of pericytes and the overlap with NAGO decreased with tPA but recovered with edaravone 4 days after tMCAO with proliferation.Thus, tPA treatment damaged pericytes, resulting in the detachment from astrocytes and a decrease in glial cell line-derived neurotrophic factor secretion.However, treatment with edaravone greatly improved tPA-induced damage to pericytes.
Affiliation: Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.Show MeSH
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Mentions: The double-fluorescence study showed that PDGFRβ-positive cells (Fig. 4, red) were double positive (arrowheads), with a smaller number of Ki67-positive cells (Fig. 4, green) in the V + tPA group (68.1 ± 10.4/mm2, P < 0.01) than in the V + V group (128.5 ± 15.8/mm2). On the other hand, the double-positive cells increased greatly in the E + V group (204.2 ± 8.5/mm2, P < 0.01 vs. V + V and V + tPA groups) compared with the V + V and the V + tPA groups. In addition, the double-positive cells in the E + tPA group (139.9 ± 10.4/mm2) increased significantly (P < 0.01) more than the V + tPA group and decreased (P < 0.01) relative to the E + V group (Fig. 4B).
Affiliation: Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.