Pericyte protection by edaravone after tissue plasminogen activator treatment in rat cerebral ischemia.
Bottom Line: The number of pericytes and the overlap with NAGO decreased with tPA but recovered with edaravone 4 days after tMCAO with proliferation.Thus, tPA treatment damaged pericytes, resulting in the detachment from astrocytes and a decrease in glial cell line-derived neurotrophic factor secretion.However, treatment with edaravone greatly improved tPA-induced damage to pericytes.
Affiliation: Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.Show MeSH
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Mentions: The double-fluorescence study showed that PDGFRβ-positive cells (Fig. 2, red) were double positive with a small number of Ki67-positive cells (Fig. 2, green) in the SC group (7.5 ± 10.4/mm2) at 1 day (18.9 ± 13.4/mm2). The number of double-positive cells increased significantly, peaking at 4 days (Fig. 2, arrowheads; 132.3 ± 29.8/mm2, P < 0.01 vs. SC) and 14 days (Fig. 2, arrowheads; 71.8 ± 15.8/mm2, P < 0.01 vs. SC).
Affiliation: Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.