Tension force-induced ATP promotes osteogenesis through P2X7 receptor in osteoblasts.
Bottom Line: TF significantly increased extracellular ATP release compared to control.Six percent TF had maximum effect on ATP release compared to 18% TF and control.A438079 blocked the stimulatory effect of 6% TF on the expression of Runx2, Osterix and ECMPs, ALP activity, and calcium content in ECM.
Affiliation: Nihon University Graduate School of Dentistry, Tokyo, Japan.Show MeSH
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Mentions: We investigated the effect of TF stimulation on extracellular ATP release in osteoblasts. Both 6% and 18% TF stimulation enhanced extracellular ATP release in the culture media compared to control at 1 min, respectively. Six percent TF enhanced the extracellular ATP release compared to 18% TF (Fig. 1).
Affiliation: Nihon University Graduate School of Dentistry, Tokyo, Japan.