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The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction.

Curtis NJ, Noble F, Bailey IS, Kelly JJ, Byrne JP, Underwood TJ - J Surg Oncol (2013)

Bottom Line: There were no significant differences in age, sex, pT stage, pN stage, pM stage, ASA, or inpatient complications between patients with adenocarcinoma based on their Siewert classification.Type III: 2.64 years; P = 0.04).The surgical approach did not influence survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

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Kaplan–Meier graph showing overall survival by Siewert grouping (P = 0.04).
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fig01: Kaplan–Meier graph showing overall survival by Siewert grouping (P = 0.04).

Mentions: Median follow-up was 2.94 years. Median overall survival for the full cohort was 3.4 years (95% confidence interval (CI) 2.14–4.66). Median overall survival was significantly shorter for more distal tumours (Type I: 4.96 years (95% CI: 4.12–5.23) vs. Type II: 3.3 years (95% CI: 2.63–4.04) vs. Type III: 2.64 years (2.04–3.63); P = 0.04). The surgical approach did not influence survival for all tumour types. Three-year overall survival was significantly better for more proximal tumours and decreased for more distal tumours (Type I: 78%, Type II: 60% HR 1.54 (95% CI: 0.81–2.92), Type III: 37% HR 2.28 (95% CI: 1.17–4.45); P = 0.011 (Fig. 1)).


The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction.

Curtis NJ, Noble F, Bailey IS, Kelly JJ, Byrne JP, Underwood TJ - J Surg Oncol (2013)

Kaplan–Meier graph showing overall survival by Siewert grouping (P = 0.04).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263256&req=5

fig01: Kaplan–Meier graph showing overall survival by Siewert grouping (P = 0.04).
Mentions: Median follow-up was 2.94 years. Median overall survival for the full cohort was 3.4 years (95% confidence interval (CI) 2.14–4.66). Median overall survival was significantly shorter for more distal tumours (Type I: 4.96 years (95% CI: 4.12–5.23) vs. Type II: 3.3 years (95% CI: 2.63–4.04) vs. Type III: 2.64 years (2.04–3.63); P = 0.04). The surgical approach did not influence survival for all tumour types. Three-year overall survival was significantly better for more proximal tumours and decreased for more distal tumours (Type I: 78%, Type II: 60% HR 1.54 (95% CI: 0.81–2.92), Type III: 37% HR 2.28 (95% CI: 1.17–4.45); P = 0.011 (Fig. 1)).

Bottom Line: There were no significant differences in age, sex, pT stage, pN stage, pM stage, ASA, or inpatient complications between patients with adenocarcinoma based on their Siewert classification.Type III: 2.64 years; P = 0.04).The surgical approach did not influence survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Show MeSH
Related in: MedlinePlus