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Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Bottom Line: After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers.

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

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Distribution of ulcers related to the coverage with fibrin and necrotic tissue and to ulcer duration (a). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, the proportion of fibrin and necrotic tissue had decreased to <50% of the wound surface in 12 of 22 wounds. In the amorphous hydrogel group, 2 of 30 wounds had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, 7 of 30 wounds were covered with <50% fibrin and necrotic tissue. Distribution of ulcers related to the coverage with granulation tissue and to the duration (b). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had >50% surface coverage with granulation tissue at day 0. After 14 days, in 11 of 22 wounds the proportion of granulation tissue had increased to >50%. In the amorphous hydrogel group, 2 of 30 wounds had >50% surface coverage with granulation tissue at day 0. After 14 days, the number increased to 6 of 30 wounds.
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fig06: Distribution of ulcers related to the coverage with fibrin and necrotic tissue and to ulcer duration (a). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, the proportion of fibrin and necrotic tissue had decreased to <50% of the wound surface in 12 of 22 wounds. In the amorphous hydrogel group, 2 of 30 wounds had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, 7 of 30 wounds were covered with <50% fibrin and necrotic tissue. Distribution of ulcers related to the coverage with granulation tissue and to the duration (b). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had >50% surface coverage with granulation tissue at day 0. After 14 days, in 11 of 22 wounds the proportion of granulation tissue had increased to >50%. In the amorphous hydrogel group, 2 of 30 wounds had >50% surface coverage with granulation tissue at day 0. After 14 days, the number increased to 6 of 30 wounds.

Mentions: On day 0, no hard-to-heal ulcer to be treated with PA-based hydrogel had <50% surface coverage by fibrin and necrotic tissue compared to 2 of 30 ulcers (6.67%) in the amorphous hydrogel group (Fig.6a). After 14 days of treatment, 12 of 22 (54.5%) hard-to-heal ulcers treated with PA-based hydrogel had <50% surface coverage by fibrin and necrotic tissue compared to 7 of 30 ulcers (23.3%) in the amorphous hydrogel group (P = 0.0209; χ2-test) (Fig.6a).


Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Distribution of ulcers related to the coverage with fibrin and necrotic tissue and to ulcer duration (a). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, the proportion of fibrin and necrotic tissue had decreased to <50% of the wound surface in 12 of 22 wounds. In the amorphous hydrogel group, 2 of 30 wounds had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, 7 of 30 wounds were covered with <50% fibrin and necrotic tissue. Distribution of ulcers related to the coverage with granulation tissue and to the duration (b). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had >50% surface coverage with granulation tissue at day 0. After 14 days, in 11 of 22 wounds the proportion of granulation tissue had increased to >50%. In the amorphous hydrogel group, 2 of 30 wounds had >50% surface coverage with granulation tissue at day 0. After 14 days, the number increased to 6 of 30 wounds.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4263240&req=5

fig06: Distribution of ulcers related to the coverage with fibrin and necrotic tissue and to ulcer duration (a). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, the proportion of fibrin and necrotic tissue had decreased to <50% of the wound surface in 12 of 22 wounds. In the amorphous hydrogel group, 2 of 30 wounds had <50% surface coverage with fibrin and necrotic tissue at day 0. After 14 days, 7 of 30 wounds were covered with <50% fibrin and necrotic tissue. Distribution of ulcers related to the coverage with granulation tissue and to the duration (b). In the PA-based hydrogel group, none of the hard-to-heal ulcers (>6 months duration) had >50% surface coverage with granulation tissue at day 0. After 14 days, in 11 of 22 wounds the proportion of granulation tissue had increased to >50%. In the amorphous hydrogel group, 2 of 30 wounds had >50% surface coverage with granulation tissue at day 0. After 14 days, the number increased to 6 of 30 wounds.
Mentions: On day 0, no hard-to-heal ulcer to be treated with PA-based hydrogel had <50% surface coverage by fibrin and necrotic tissue compared to 2 of 30 ulcers (6.67%) in the amorphous hydrogel group (Fig.6a). After 14 days of treatment, 12 of 22 (54.5%) hard-to-heal ulcers treated with PA-based hydrogel had <50% surface coverage by fibrin and necrotic tissue compared to 7 of 30 ulcers (23.3%) in the amorphous hydrogel group (P = 0.0209; χ2-test) (Fig.6a).

Bottom Line: After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers.

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

Show MeSH
Related in: MedlinePlus