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Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Bottom Line: We tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease-modulating properties.After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

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Odds ratio for the possibility of having <50% fibrin and necrotic tissue or having >50% granulation tissue after 14 days of treatment with either the PA-based hydrogel or the amorphous hydrogel compared to each other.
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fig05: Odds ratio for the possibility of having <50% fibrin and necrotic tissue or having >50% granulation tissue after 14 days of treatment with either the PA-based hydrogel or the amorphous hydrogel compared to each other.

Mentions: On day 14, 16 of 34 (47.1%) ulcers treated with PA-based hydrogel had >50% surface coverage with granulation tissue compared to 9 of 41 (23.1%) in the amorphous hydrogel group (P = 0.0217; χ2-test) (Fig.4b). In the two treatment groups, the probability of having >50% covered with granulation tissue on day 14 was 3; 16 times higher for wounds treated with the PA-based hydrogel (OR = 3.16; 95% CI = 1.16–8.59) (Fig.5).


Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Odds ratio for the possibility of having <50% fibrin and necrotic tissue or having >50% granulation tissue after 14 days of treatment with either the PA-based hydrogel or the amorphous hydrogel compared to each other.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263240&req=5

fig05: Odds ratio for the possibility of having <50% fibrin and necrotic tissue or having >50% granulation tissue after 14 days of treatment with either the PA-based hydrogel or the amorphous hydrogel compared to each other.
Mentions: On day 14, 16 of 34 (47.1%) ulcers treated with PA-based hydrogel had >50% surface coverage with granulation tissue compared to 9 of 41 (23.1%) in the amorphous hydrogel group (P = 0.0217; χ2-test) (Fig.4b). In the two treatment groups, the probability of having >50% covered with granulation tissue on day 14 was 3; 16 times higher for wounds treated with the PA-based hydrogel (OR = 3.16; 95% CI = 1.16–8.59) (Fig.5).

Bottom Line: We tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease-modulating properties.After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

Show MeSH
Related in: MedlinePlus