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Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Bottom Line: After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers.

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

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Absolute increase in granulation tissue (a). Cumulative distribution of the absolute change in the amount of granulation tissue at day14 after treatment with either the PA-based hydrogel or the amorphous hydrogel (b). The graph representing the wounds treated with PA-based hydrogel is clearly shifted to the right. Each point represents one wound.
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fig04: Absolute increase in granulation tissue (a). Cumulative distribution of the absolute change in the amount of granulation tissue at day14 after treatment with either the PA-based hydrogel or the amorphous hydrogel (b). The graph representing the wounds treated with PA-based hydrogel is clearly shifted to the right. Each point represents one wound.

Mentions: Both the PA-based and amorphous hydrogel dressings increased the proportion of granulation tissue within 14 days. The proportion of ulcer area covered by granulation tissue increased by 36.0 ± 27.4 percentage points in the PA-based hydrogel group and by 14.5 ± 22.0 percentage points in the amorphous hydrogel group compared to the baseline (P = 0.005) (Fig.4a). The cumulative distribution indicates a preferential induction of granulation tissue formation (Fig.4b).


Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Absolute increase in granulation tissue (a). Cumulative distribution of the absolute change in the amount of granulation tissue at day14 after treatment with either the PA-based hydrogel or the amorphous hydrogel (b). The graph representing the wounds treated with PA-based hydrogel is clearly shifted to the right. Each point represents one wound.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263240&req=5

fig04: Absolute increase in granulation tissue (a). Cumulative distribution of the absolute change in the amount of granulation tissue at day14 after treatment with either the PA-based hydrogel or the amorphous hydrogel (b). The graph representing the wounds treated with PA-based hydrogel is clearly shifted to the right. Each point represents one wound.
Mentions: Both the PA-based and amorphous hydrogel dressings increased the proportion of granulation tissue within 14 days. The proportion of ulcer area covered by granulation tissue increased by 36.0 ± 27.4 percentage points in the PA-based hydrogel group and by 14.5 ± 22.0 percentage points in the amorphous hydrogel group compared to the baseline (P = 0.005) (Fig.4a). The cumulative distribution indicates a preferential induction of granulation tissue formation (Fig.4b).

Bottom Line: After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers.

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

Show MeSH
Related in: MedlinePlus