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Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Bottom Line: After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers.

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

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At day 0 the wound was 90% covered with fibrin and necrotic tissue related to the total wound area (= 100%). At day 14, the proportion of fibrin and necrotic tissue was reduced to 8% of the total wound area. This decrease (90%–8%) corresponds to a difference of 82 percentage points (synonymic with the term ‘absolute reduction’ used in the present report). This difference is equivalent to a percent reduction in fibrin and necrotic tissue of 91.1% related to the proportion of 90% fibrin and necrotic tissue on day 0.
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fig02: At day 0 the wound was 90% covered with fibrin and necrotic tissue related to the total wound area (= 100%). At day 14, the proportion of fibrin and necrotic tissue was reduced to 8% of the total wound area. This decrease (90%–8%) corresponds to a difference of 82 percentage points (synonymic with the term ‘absolute reduction’ used in the present report). This difference is equivalent to a percent reduction in fibrin and necrotic tissue of 91.1% related to the proportion of 90% fibrin and necrotic tissue on day 0.

Mentions: Absolute reduction in the proportion of fibrin and necroses covering the wound area on day 14 (or earlier for early withdrawal) compared to the baseline (for definition of ‘absolute reduction’ see Fig.2). For further analysis, wounds were grouped into those with <50% surface coverage with slough and those with ≥50% slough and necroses.Figure 2


Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

At day 0 the wound was 90% covered with fibrin and necrotic tissue related to the total wound area (= 100%). At day 14, the proportion of fibrin and necrotic tissue was reduced to 8% of the total wound area. This decrease (90%–8%) corresponds to a difference of 82 percentage points (synonymic with the term ‘absolute reduction’ used in the present report). This difference is equivalent to a percent reduction in fibrin and necrotic tissue of 91.1% related to the proportion of 90% fibrin and necrotic tissue on day 0.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263240&req=5

fig02: At day 0 the wound was 90% covered with fibrin and necrotic tissue related to the total wound area (= 100%). At day 14, the proportion of fibrin and necrotic tissue was reduced to 8% of the total wound area. This decrease (90%–8%) corresponds to a difference of 82 percentage points (synonymic with the term ‘absolute reduction’ used in the present report). This difference is equivalent to a percent reduction in fibrin and necrotic tissue of 91.1% related to the proportion of 90% fibrin and necrotic tissue on day 0.
Mentions: Absolute reduction in the proportion of fibrin and necroses covering the wound area on day 14 (or earlier for early withdrawal) compared to the baseline (for definition of ‘absolute reduction’ see Fig.2). For further analysis, wounds were grouped into those with <50% surface coverage with slough and those with ≥50% slough and necroses.Figure 2

Bottom Line: After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers.

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

Show MeSH
Related in: MedlinePlus