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Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Bottom Line: We tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease-modulating properties.After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

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Related in: MedlinePlus

Flow diagram of the patients involved in the study. The results shown in the present report were based on the ITT-population.
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fig01: Flow diagram of the patients involved in the study. The results shown in the present report were based on the ITT-population.

Mentions: Patients were screened for up to 3 days to confirm selection criteria (Fig.1). If all inclusion criteria were met, patients were randomized (day 0) for treatment with the PA-based hydrogel or the amorphous hydrogel for 2 weeks, including a detailed wound evaluation on days 7 and 14.


Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers--a randomized controlled trial.

Humbert P, Faivre B, Véran Y, Debure C, Truchetet F, Bécherel PA, Plantin P, Kerihuel JC, Eming SA, Dissemond J, Weyandt G, Kaspar D, Smola H, Zöllner P, CLEANSITE study gro - J Eur Acad Dermatol Venereol (2014)

Flow diagram of the patients involved in the study. The results shown in the present report were based on the ITT-population.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263240&req=5

fig01: Flow diagram of the patients involved in the study. The results shown in the present report were based on the ITT-population.
Mentions: Patients were screened for up to 3 days to confirm selection criteria (Fig.1). If all inclusion criteria were met, patients were randomized (day 0) for treatment with the PA-based hydrogel or the amorphous hydrogel for 2 weeks, including a detailed wound evaluation on days 7 and 14.

Bottom Line: We tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease-modulating properties.After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6 ± 29.9 percentage points in the PA-based hydrogel group and by 16.8 ± 23.0 percentage points in the amorphous hydrogel group.The differences between the groups were significant (decrease in fibrin and necrotic tissue P = 0.004 and increase in granulation tissue P = 0.0005, respectively).

View Article: PubMed Central - PubMed

Affiliation: Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, France.

Show MeSH
Related in: MedlinePlus