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HIV co-infection accelerates decay of humoral responses in spontaneous resolvers of HCV infection.

Liu Y, Shen T, Zhang C, Long L, Duan Z, Lu F - J. Viral Hepat. (2014)

Bottom Line: We found that the annual decreasing rate of anti-HCV presented a gradually accelerated process in HCV resolvers.However, the variation in the decline of anti-HCV presented a slowly accelerated process within the early decrease stage and a gradually decelerated process within the latter decrease stage.Our data indicated that the decay of anti-HCV was accelerated by HIV-related impairment of immune function.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Peking University Health Science Center, Beijing, China; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Henan, China.

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HIV-related immune dysfunction enhanced the decreasing rate of hepatitis C virus (HCV)-specific antibody responses in HCV resolvers. (a)HCV-specific antibody responses decreased as time progressed in HCV spontaneous resolvers, while no decreasing trends of HCV antibody titres were found in chronic HCV carriers. The anti-HCV titres in four different groups (HIVneg chronic HCV, HIVpos chronic HCV, HIVneg SR-HCV and HIVpos SR-HCV) between 2009 and 2012 were analysed by the paired comparison method. (b) Comparison of the annual decreasing rate of HCV-specific antibody S/CO values between HIV-uninfected and HIV-infected subjects. (c) The annual decreasing rates of HCV-specific antibodies of HIV-infected patients correlate negatively with peripheral CD4+ T-cell counts in HIV-infected patients. *P < 0.05; ***P < 0.001.
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fig01: HIV-related immune dysfunction enhanced the decreasing rate of hepatitis C virus (HCV)-specific antibody responses in HCV resolvers. (a)HCV-specific antibody responses decreased as time progressed in HCV spontaneous resolvers, while no decreasing trends of HCV antibody titres were found in chronic HCV carriers. The anti-HCV titres in four different groups (HIVneg chronic HCV, HIVpos chronic HCV, HIVneg SR-HCV and HIVpos SR-HCV) between 2009 and 2012 were analysed by the paired comparison method. (b) Comparison of the annual decreasing rate of HCV-specific antibody S/CO values between HIV-uninfected and HIV-infected subjects. (c) The annual decreasing rates of HCV-specific antibodies of HIV-infected patients correlate negatively with peripheral CD4+ T-cell counts in HIV-infected patients. *P < 0.05; ***P < 0.001.

Mentions: To provide evidence in support of the widely held belief that anti-HCV decreases gradually with time after an individual acquires SR-HCV status, anti-HCV titres of patients in the four different groups obtained in 2009 were compared with those measured in 2012. This revealed that anti-HCV gradually decreased over a 3-year period in both HIVneg SR-HCV (P < 0.001) and HIVpos SR-HCV (P < 0.001) (Fig. 1a). By contrast, no such differences were found in the HIVneg chronic HCV and HIVpos chronic HCV groups (Fig. 1a). The profiles of the anti-HCV in HCV resolvers were retested by RIBA assay subsequently. We found that anti-HCV responses induced by the core and NS3 proteins were the primary components of anti-HCV as measured by the CMIA assay (Figure S3).


HIV co-infection accelerates decay of humoral responses in spontaneous resolvers of HCV infection.

Liu Y, Shen T, Zhang C, Long L, Duan Z, Lu F - J. Viral Hepat. (2014)

HIV-related immune dysfunction enhanced the decreasing rate of hepatitis C virus (HCV)-specific antibody responses in HCV resolvers. (a)HCV-specific antibody responses decreased as time progressed in HCV spontaneous resolvers, while no decreasing trends of HCV antibody titres were found in chronic HCV carriers. The anti-HCV titres in four different groups (HIVneg chronic HCV, HIVpos chronic HCV, HIVneg SR-HCV and HIVpos SR-HCV) between 2009 and 2012 were analysed by the paired comparison method. (b) Comparison of the annual decreasing rate of HCV-specific antibody S/CO values between HIV-uninfected and HIV-infected subjects. (c) The annual decreasing rates of HCV-specific antibodies of HIV-infected patients correlate negatively with peripheral CD4+ T-cell counts in HIV-infected patients. *P < 0.05; ***P < 0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263235&req=5

fig01: HIV-related immune dysfunction enhanced the decreasing rate of hepatitis C virus (HCV)-specific antibody responses in HCV resolvers. (a)HCV-specific antibody responses decreased as time progressed in HCV spontaneous resolvers, while no decreasing trends of HCV antibody titres were found in chronic HCV carriers. The anti-HCV titres in four different groups (HIVneg chronic HCV, HIVpos chronic HCV, HIVneg SR-HCV and HIVpos SR-HCV) between 2009 and 2012 were analysed by the paired comparison method. (b) Comparison of the annual decreasing rate of HCV-specific antibody S/CO values between HIV-uninfected and HIV-infected subjects. (c) The annual decreasing rates of HCV-specific antibodies of HIV-infected patients correlate negatively with peripheral CD4+ T-cell counts in HIV-infected patients. *P < 0.05; ***P < 0.001.
Mentions: To provide evidence in support of the widely held belief that anti-HCV decreases gradually with time after an individual acquires SR-HCV status, anti-HCV titres of patients in the four different groups obtained in 2009 were compared with those measured in 2012. This revealed that anti-HCV gradually decreased over a 3-year period in both HIVneg SR-HCV (P < 0.001) and HIVpos SR-HCV (P < 0.001) (Fig. 1a). By contrast, no such differences were found in the HIVneg chronic HCV and HIVpos chronic HCV groups (Fig. 1a). The profiles of the anti-HCV in HCV resolvers were retested by RIBA assay subsequently. We found that anti-HCV responses induced by the core and NS3 proteins were the primary components of anti-HCV as measured by the CMIA assay (Figure S3).

Bottom Line: We found that the annual decreasing rate of anti-HCV presented a gradually accelerated process in HCV resolvers.However, the variation in the decline of anti-HCV presented a slowly accelerated process within the early decrease stage and a gradually decelerated process within the latter decrease stage.Our data indicated that the decay of anti-HCV was accelerated by HIV-related impairment of immune function.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Peking University Health Science Center, Beijing, China; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Henan, China.

Show MeSH
Related in: MedlinePlus