HIV co-infection accelerates decay of humoral responses in spontaneous resolvers of HCV infection.
Bottom Line: We found that the annual decreasing rate of anti-HCV presented a gradually accelerated process in HCV resolvers.However, the variation in the decline of anti-HCV presented a slowly accelerated process within the early decrease stage and a gradually decelerated process within the latter decrease stage.Our data indicated that the decay of anti-HCV was accelerated by HIV-related impairment of immune function.
Affiliation: Department of Microbiology, Peking University Health Science Center, Beijing, China; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Henan, China.Show MeSH
Related in: MedlinePlus
Mentions: To provide evidence in support of the widely held belief that anti-HCV decreases gradually with time after an individual acquires SR-HCV status, anti-HCV titres of patients in the four different groups obtained in 2009 were compared with those measured in 2012. This revealed that anti-HCV gradually decreased over a 3-year period in both HIVneg SR-HCV (P < 0.001) and HIVpos SR-HCV (P < 0.001) (Fig. 1a). By contrast, no such differences were found in the HIVneg chronic HCV and HIVpos chronic HCV groups (Fig. 1a). The profiles of the anti-HCV in HCV resolvers were retested by RIBA assay subsequently. We found that anti-HCV responses induced by the core and NS3 proteins were the primary components of anti-HCV as measured by the CMIA assay (Figure S3).
Affiliation: Department of Microbiology, Peking University Health Science Center, Beijing, China; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Henan, China.