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Lifestyle factors, demographics and medications associated with depression risk in an international sample of people with multiple sclerosis.

Taylor KL, Hadgkiss EJ, Jelinek GA, Weiland TJ, Pereira NG, Marck CH, van der Meer DM - BMC Psychiatry (2014)

Bottom Line: This cross-sectional analysis recruited a total of 2459 participants via Web 2.0 platforms.Regression analyses showed that poor diet, low levels of exercise, obesity, smoking, marked social isolation and taking interferon were associated with greater depression risk.Participants who supplemented with omega 3s, particularly flaxseed oil, had frequent fish consumption, supplemented with vitamin D, meditated, and had moderate alcohol consumption had significantly reduced depression risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, St Vincent's Hospital Melbourne, Victoria, VIC, 3065, Australia. keryn.taylor@svha.org.au.

ABSTRACT

Background: Depression is the most common co-morbidity for people with Multiple Sclerosis (MS); irrespective of disease severity, depression has the greatest impact on quality of life. An emerging paradigm in the treatment of depression is lifestyle medicine. There is significant potential to prevent and treat depression through modification of lifestyle risk factors for people with MS. This study sought to understand the association between lifestyle risk factors, medication and depression risk through the analysis of self-reported data from a large international sample of people with MS.

Methods: This cross-sectional analysis recruited a total of 2459 participants via Web 2.0 platforms. Survey data included socio-demographics; a range of lifestyle risk factors; medication; disease variables and depression risk using the Patient Health Questionnaire-2 (PHQ-2).

Results: In total approximately one fifth (19.3%) of our sample screened positive for depression (PHQ-2 score ≥3). Several demographic factors were significantly associated with this depression risk in bivariate analysis. Regression analyses showed that poor diet, low levels of exercise, obesity, smoking, marked social isolation and taking interferon were associated with greater depression risk. Participants who supplemented with omega 3s, particularly flaxseed oil, had frequent fish consumption, supplemented with vitamin D, meditated, and had moderate alcohol consumption had significantly reduced depression risk.

Conclusions: This study demonstrates a significant association between modifiable lifestyle factors and depression risk. Planned longitudinal follow up may clarify causality. Clinicians and people with MS should be aware of the wide range of modifiable lifestyle factors that may reduce depression risk as part of a comprehensive secondary and tertiary preventive medical approach to managing MS.

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Related in: MedlinePlus

Associations between lifestyle factors and depression screen.
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Fig1: Associations between lifestyle factors and depression screen.

Mentions: A number of modifiable lifestyle factors were significantly associated with depression risk in regression analyses adjusted for years since diagnosis, number of comorbidities, level of disability, clinically significant fatigue, age, gender, level of education and marital status. Figure 1 shows associations between depression screen and vitamin D supplementation, fish consumption, dietary habits and physical activity. Table 3 shows crude and adjusted odds ratios with 95% confidence intervals.Figure 1


Lifestyle factors, demographics and medications associated with depression risk in an international sample of people with multiple sclerosis.

Taylor KL, Hadgkiss EJ, Jelinek GA, Weiland TJ, Pereira NG, Marck CH, van der Meer DM - BMC Psychiatry (2014)

Associations between lifestyle factors and depression screen.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4263016&req=5

Fig1: Associations between lifestyle factors and depression screen.
Mentions: A number of modifiable lifestyle factors were significantly associated with depression risk in regression analyses adjusted for years since diagnosis, number of comorbidities, level of disability, clinically significant fatigue, age, gender, level of education and marital status. Figure 1 shows associations between depression screen and vitamin D supplementation, fish consumption, dietary habits and physical activity. Table 3 shows crude and adjusted odds ratios with 95% confidence intervals.Figure 1

Bottom Line: This cross-sectional analysis recruited a total of 2459 participants via Web 2.0 platforms.Regression analyses showed that poor diet, low levels of exercise, obesity, smoking, marked social isolation and taking interferon were associated with greater depression risk.Participants who supplemented with omega 3s, particularly flaxseed oil, had frequent fish consumption, supplemented with vitamin D, meditated, and had moderate alcohol consumption had significantly reduced depression risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, St Vincent's Hospital Melbourne, Victoria, VIC, 3065, Australia. keryn.taylor@svha.org.au.

ABSTRACT

Background: Depression is the most common co-morbidity for people with Multiple Sclerosis (MS); irrespective of disease severity, depression has the greatest impact on quality of life. An emerging paradigm in the treatment of depression is lifestyle medicine. There is significant potential to prevent and treat depression through modification of lifestyle risk factors for people with MS. This study sought to understand the association between lifestyle risk factors, medication and depression risk through the analysis of self-reported data from a large international sample of people with MS.

Methods: This cross-sectional analysis recruited a total of 2459 participants via Web 2.0 platforms. Survey data included socio-demographics; a range of lifestyle risk factors; medication; disease variables and depression risk using the Patient Health Questionnaire-2 (PHQ-2).

Results: In total approximately one fifth (19.3%) of our sample screened positive for depression (PHQ-2 score ≥3). Several demographic factors were significantly associated with this depression risk in bivariate analysis. Regression analyses showed that poor diet, low levels of exercise, obesity, smoking, marked social isolation and taking interferon were associated with greater depression risk. Participants who supplemented with omega 3s, particularly flaxseed oil, had frequent fish consumption, supplemented with vitamin D, meditated, and had moderate alcohol consumption had significantly reduced depression risk.

Conclusions: This study demonstrates a significant association between modifiable lifestyle factors and depression risk. Planned longitudinal follow up may clarify causality. Clinicians and people with MS should be aware of the wide range of modifiable lifestyle factors that may reduce depression risk as part of a comprehensive secondary and tertiary preventive medical approach to managing MS.

Show MeSH
Related in: MedlinePlus