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Effect of FTO Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population.

Payne A, Cahill F, Sun G, Loredo-Osti JC, Abarin T - Genet Epigenet (2014)

Bottom Line: For highly active males, trunk fat percentage varied significantly between variants of rs9939609 and rs1421085, but there is no significant effect among individuals with low activity.Homozygous male carriers of non-obesity risk alleles at rs9939609 and rs1421085 will have significant reduction in central body fat from physical activity in contrast to homozygous males of the obesity-risk alleles.The additive effect of these SNPs is found in males with high physical activity only.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, Memorial University, St. John's, NL, Canada.

ABSTRACT

Objective: To explore the effect of FTO gene and physical activity interaction on trunk fat percentage.

Design and methods: Subjects are 3,004 individuals from Newfoundland and Labrador whose trunk fat percentage and physical activity were recorded, and who were genotyped for 11 single-nucleotide polymorphisms (SNPs) in the FTO gene. Subjects were stratified by gender. Multiple tests and multiple regressions were used to analyze the effects of physical activity, variants of FTO, age, and their interactions on trunk fat percentage. Dietary information and other environmental factors were not considered.

Results: Higher levels of physical activity tend to reduce trunk fat percentage in all individuals. Furthermore, in males, rs9939609 and rs1421085 were significant (α = 0.05) in explaining central body fat, but no SNPs were significant in females. For highly active males, trunk fat percentage varied significantly between variants of rs9939609 and rs1421085, but there is no significant effect among individuals with low activity. The other SNPs examined were not significant in explaining trunk fat percentage.

Conclusions: Homozygous male carriers of non-obesity risk alleles at rs9939609 and rs1421085 will have significant reduction in central body fat from physical activity in contrast to homozygous males of the obesity-risk alleles. The additive effect of these SNPs is found in males with high physical activity only.

No MeSH data available.


Related in: MedlinePlus

Graphs showing the effects of different levels of physical activity on trunk fat percentage for males and females, by age. Percent trunk fat is measured in percentage (%), and age is measured in years.
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f2-geg-6-2014-021: Graphs showing the effects of different levels of physical activity on trunk fat percentage for males and females, by age. Percent trunk fat is measured in percentage (%), and age is measured in years.

Mentions: The three categories of physical activity in this study were introduced as two dummy variables: moderate activity and high activity. Physical activity on its own is a significant explanatory variable for trunk fat percentage, for both males and females. Young females with high levels of physical activity appeared to have lower trunk fat percentage than young inactive females, and this effect seemed to decrease as age increased (although the effect was not statistically significant). The same relationship was not apparent for males (Fig. 2). For males studied, mean trunk fat percentages for individuals with low, moderate, and high activity were 34.6, 29.6, and 22.8, respectively. For females, these values were 42.2, 38.4, and 31.6, respectively. Trunk fat percentages for high and low activity were significantly different for both males and females (P = 0). Although increased physical activity results in decreased trunk fat percentage, the following section describes how the magnitude of this effect may change with age and genotype of the SNPs explored in this study.


Effect of FTO Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population.

Payne A, Cahill F, Sun G, Loredo-Osti JC, Abarin T - Genet Epigenet (2014)

Graphs showing the effects of different levels of physical activity on trunk fat percentage for males and females, by age. Percent trunk fat is measured in percentage (%), and age is measured in years.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4262999&req=5

f2-geg-6-2014-021: Graphs showing the effects of different levels of physical activity on trunk fat percentage for males and females, by age. Percent trunk fat is measured in percentage (%), and age is measured in years.
Mentions: The three categories of physical activity in this study were introduced as two dummy variables: moderate activity and high activity. Physical activity on its own is a significant explanatory variable for trunk fat percentage, for both males and females. Young females with high levels of physical activity appeared to have lower trunk fat percentage than young inactive females, and this effect seemed to decrease as age increased (although the effect was not statistically significant). The same relationship was not apparent for males (Fig. 2). For males studied, mean trunk fat percentages for individuals with low, moderate, and high activity were 34.6, 29.6, and 22.8, respectively. For females, these values were 42.2, 38.4, and 31.6, respectively. Trunk fat percentages for high and low activity were significantly different for both males and females (P = 0). Although increased physical activity results in decreased trunk fat percentage, the following section describes how the magnitude of this effect may change with age and genotype of the SNPs explored in this study.

Bottom Line: For highly active males, trunk fat percentage varied significantly between variants of rs9939609 and rs1421085, but there is no significant effect among individuals with low activity.Homozygous male carriers of non-obesity risk alleles at rs9939609 and rs1421085 will have significant reduction in central body fat from physical activity in contrast to homozygous males of the obesity-risk alleles.The additive effect of these SNPs is found in males with high physical activity only.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, Memorial University, St. John's, NL, Canada.

ABSTRACT

Objective: To explore the effect of FTO gene and physical activity interaction on trunk fat percentage.

Design and methods: Subjects are 3,004 individuals from Newfoundland and Labrador whose trunk fat percentage and physical activity were recorded, and who were genotyped for 11 single-nucleotide polymorphisms (SNPs) in the FTO gene. Subjects were stratified by gender. Multiple tests and multiple regressions were used to analyze the effects of physical activity, variants of FTO, age, and their interactions on trunk fat percentage. Dietary information and other environmental factors were not considered.

Results: Higher levels of physical activity tend to reduce trunk fat percentage in all individuals. Furthermore, in males, rs9939609 and rs1421085 were significant (α = 0.05) in explaining central body fat, but no SNPs were significant in females. For highly active males, trunk fat percentage varied significantly between variants of rs9939609 and rs1421085, but there is no significant effect among individuals with low activity. The other SNPs examined were not significant in explaining trunk fat percentage.

Conclusions: Homozygous male carriers of non-obesity risk alleles at rs9939609 and rs1421085 will have significant reduction in central body fat from physical activity in contrast to homozygous males of the obesity-risk alleles. The additive effect of these SNPs is found in males with high physical activity only.

No MeSH data available.


Related in: MedlinePlus