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Aqueous seed extract of Cola nitida rubra reduces serum reproductive hormone concentrations and sperm count in adult male albino Wistar rats.

Umoh IO, Emmanuel OA, Nna VU - Niger Med J (2014)

Bottom Line: Serum concentrations of luteinizing hormone (LH) and testosterone were significantly (P < 0.05) reduced in test 2 and 3, compared with control.There was no significant difference in testicular and epididymis weight in the different experimental groups studied.Aqueous seed extract of Cola nitida rubra resulted in reduced serum reproductive hormone concentrations and sperm count in male wistar rats, and may therefore be detrimental to reproductive health, hence the need for regulation of its consumption.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom, Nigeria.

ABSTRACT

Background: Following the high rate of consumption of Cola nitida (cola nut) among the male population in Nigeria, this study seeks to determine the effects of consumption of Cola nitida on serum reproductive hormones and sperm count, which are major determinants of male fertility.

Materials and methods: Thirty-two male albino wistar rats weighing 180-220 g were used for this study and were divided into 4 groups of eight animals each. Group 1 served as control, group 2 received 2 mg/kg Cola nitida extract (Test 1), group 3 received 6 mg/kg Cola nitida extract (Test 2) and group 4 received 10 mg/kg Cola nitida extract (Test 3). After 6 weeks of treatment, reproductive hormonal assay was carried out using the rat serum. Epididymal spermatozoa were collected and sperm count determined.

Results: Serum concentrations of luteinizing hormone (LH) and testosterone were significantly (P < 0.05) reduced in test 2 and 3, compared with control. Sperm count was significantly lower in test group 1 (P < 0.05), 2 (P < 0.001) and 3 (P < 0.001) compared with control, with test 3 significantly (P < 0.05) lower compared with test 1. There was no significant difference in testicular and epididymis weight in the different experimental groups studied.

Conclusion: Aqueous seed extract of Cola nitida rubra resulted in reduced serum reproductive hormone concentrations and sperm count in male wistar rats, and may therefore be detrimental to reproductive health, hence the need for regulation of its consumption.

No MeSH data available.


Related in: MedlinePlus

Comparison of Epididymis Weight in the different experimental groups. Values are mean ± SEM, n = 8
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Figure 4: Comparison of Epididymis Weight in the different experimental groups. Values are mean ± SEM, n = 8

Mentions: The epididymal weight for control, test group 1, 2 and 3 was 0.47 ± 0.02, 0.47 ± 0.02, 0.46 ± 0.02 and 0.45 ± 0.02 g, respectively. There was no statistically significant difference in the epididymal weight of animals in the different groups studied [Figure 4].


Aqueous seed extract of Cola nitida rubra reduces serum reproductive hormone concentrations and sperm count in adult male albino Wistar rats.

Umoh IO, Emmanuel OA, Nna VU - Niger Med J (2014)

Comparison of Epididymis Weight in the different experimental groups. Values are mean ± SEM, n = 8
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4262839&req=5

Figure 4: Comparison of Epididymis Weight in the different experimental groups. Values are mean ± SEM, n = 8
Mentions: The epididymal weight for control, test group 1, 2 and 3 was 0.47 ± 0.02, 0.47 ± 0.02, 0.46 ± 0.02 and 0.45 ± 0.02 g, respectively. There was no statistically significant difference in the epididymal weight of animals in the different groups studied [Figure 4].

Bottom Line: Serum concentrations of luteinizing hormone (LH) and testosterone were significantly (P < 0.05) reduced in test 2 and 3, compared with control.There was no significant difference in testicular and epididymis weight in the different experimental groups studied.Aqueous seed extract of Cola nitida rubra resulted in reduced serum reproductive hormone concentrations and sperm count in male wistar rats, and may therefore be detrimental to reproductive health, hence the need for regulation of its consumption.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom, Nigeria.

ABSTRACT

Background: Following the high rate of consumption of Cola nitida (cola nut) among the male population in Nigeria, this study seeks to determine the effects of consumption of Cola nitida on serum reproductive hormones and sperm count, which are major determinants of male fertility.

Materials and methods: Thirty-two male albino wistar rats weighing 180-220 g were used for this study and were divided into 4 groups of eight animals each. Group 1 served as control, group 2 received 2 mg/kg Cola nitida extract (Test 1), group 3 received 6 mg/kg Cola nitida extract (Test 2) and group 4 received 10 mg/kg Cola nitida extract (Test 3). After 6 weeks of treatment, reproductive hormonal assay was carried out using the rat serum. Epididymal spermatozoa were collected and sperm count determined.

Results: Serum concentrations of luteinizing hormone (LH) and testosterone were significantly (P < 0.05) reduced in test 2 and 3, compared with control. Sperm count was significantly lower in test group 1 (P < 0.05), 2 (P < 0.001) and 3 (P < 0.001) compared with control, with test 3 significantly (P < 0.05) lower compared with test 1. There was no significant difference in testicular and epididymis weight in the different experimental groups studied.

Conclusion: Aqueous seed extract of Cola nitida rubra resulted in reduced serum reproductive hormone concentrations and sperm count in male wistar rats, and may therefore be detrimental to reproductive health, hence the need for regulation of its consumption.

No MeSH data available.


Related in: MedlinePlus