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Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration.

Khan GH, Galazis N, Docheva N, Layfield R, Atiomo W - Hum. Reprod. (2014)

Bottom Line: The sample sizes and number of biomarkers identified from these studies do not exclude the risk of false positives, a limitation of all biomarker studies.No financial support was obtained for this project.There are no conflicts of interest.

View Article: PubMed Central - PubMed

Affiliation: Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre, D Floor, East Block, Nottingham, UK gulafshanahafeez@hotmail.com.

No MeSH data available.


Related in: MedlinePlus

Flowchart showing selection of studies included in the systematic review.
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DEU268F1: Flowchart showing selection of studies included in the systematic review.

Mentions: The selection process of the primary studies where proteomic methodologies were used for the identification of biomarkers of PE is shown in Fig. 1. The search generated 58 articles. Review articles, studies that did not use proteomic techniques or studies that did not compare PE with a normotensive (control) group were excluded. Moreover, studies involving animals only, studies presenting protein m/z values only rather than protein identifications, or those studies that compared different proteomic approaches were further excluded, leaving 16 primary studies eligible for this review (Watanabe et al., 2004; Vascotto et al., 2007; Buhimschi et al., 2008; Jin et al., 2008; Park et al., 2008; Blankley et al., 2009; Blumenstein et al., 2009a,b; Centlow et al., 2010; Gharesi-Fard et al., 2010; Rasanen et al., 2010; Johnstone et al., 2011; Liu et al., 2011; Epiney et al., 2012; Kolla et al., 2012; Myers et al., 2013).Figure 1


Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration.

Khan GH, Galazis N, Docheva N, Layfield R, Atiomo W - Hum. Reprod. (2014)

Flowchart showing selection of studies included in the systematic review.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4262466&req=5

DEU268F1: Flowchart showing selection of studies included in the systematic review.
Mentions: The selection process of the primary studies where proteomic methodologies were used for the identification of biomarkers of PE is shown in Fig. 1. The search generated 58 articles. Review articles, studies that did not use proteomic techniques or studies that did not compare PE with a normotensive (control) group were excluded. Moreover, studies involving animals only, studies presenting protein m/z values only rather than protein identifications, or those studies that compared different proteomic approaches were further excluded, leaving 16 primary studies eligible for this review (Watanabe et al., 2004; Vascotto et al., 2007; Buhimschi et al., 2008; Jin et al., 2008; Park et al., 2008; Blankley et al., 2009; Blumenstein et al., 2009a,b; Centlow et al., 2010; Gharesi-Fard et al., 2010; Rasanen et al., 2010; Johnstone et al., 2011; Liu et al., 2011; Epiney et al., 2012; Kolla et al., 2012; Myers et al., 2013).Figure 1

Bottom Line: The sample sizes and number of biomarkers identified from these studies do not exclude the risk of false positives, a limitation of all biomarker studies.No financial support was obtained for this project.There are no conflicts of interest.

View Article: PubMed Central - PubMed

Affiliation: Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre, D Floor, East Block, Nottingham, UK gulafshanahafeez@hotmail.com.

No MeSH data available.


Related in: MedlinePlus