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Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperita Grown in China.

Sun Z, Wang H, Wang J, Zhou L, Yang P - PLoS ONE (2014)

Bottom Line: It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively.The results of this study may provide an experimental basis for further systematic research, rational development and clinical utilization of peppermint resources.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 200040, China.

ABSTRACT
The chemical composition, anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita (MEO) grown in China were investigated. Using GC-MS analysis, the chemical composition of MEO was characterized, showing that it was mainly composed of menthol, menthone and menthy acetate. MEO exhibited potent anti-inflammatory activities in a croton oil-induced mouse ear edema model. It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. The cytotoxic effect was assessed against four human cancer cells. MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively. In addition, MEO had moderate antioxidant activity. The results of this study may provide an experimental basis for further systematic research, rational development and clinical utilization of peppermint resources.

No MeSH data available.


Related in: MedlinePlus

The effect of MEO against croton oil-induced ear edema in mice.Data are representative of ten experiments and as means ± SE. Indomethacin was used as a reference compound (300 µg per ear). Statistical differences from indomethacin-treated control as analyzed by Dunnett's test (** P<0.01)
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pone-0114767-g002: The effect of MEO against croton oil-induced ear edema in mice.Data are representative of ten experiments and as means ± SE. Indomethacin was used as a reference compound (300 µg per ear). Statistical differences from indomethacin-treated control as analyzed by Dunnett's test (** P<0.01)

Mentions: The anti-inflammatory activity of MEO in the croton oil-induced mouse ear edema model was evaluated in this study. As shown in Fig. 2, in comparison with the non-steroidal anti-inflammatory drug indomethacin, MEO exhibited a significantly high anti-inflammatory activity in a dose-dependent manner. In addition, MEO reduced the edematous response by 5.77%, 7.37% and 30.24% at the dose of 200, 400 and 800 µg, respectively. The mouse ear plug weight was reduced by 16.79% after indomethacin treatment (dose 300 µg per ear).


Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperita Grown in China.

Sun Z, Wang H, Wang J, Zhou L, Yang P - PLoS ONE (2014)

The effect of MEO against croton oil-induced ear edema in mice.Data are representative of ten experiments and as means ± SE. Indomethacin was used as a reference compound (300 µg per ear). Statistical differences from indomethacin-treated control as analyzed by Dunnett's test (** P<0.01)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4262447&req=5

pone-0114767-g002: The effect of MEO against croton oil-induced ear edema in mice.Data are representative of ten experiments and as means ± SE. Indomethacin was used as a reference compound (300 µg per ear). Statistical differences from indomethacin-treated control as analyzed by Dunnett's test (** P<0.01)
Mentions: The anti-inflammatory activity of MEO in the croton oil-induced mouse ear edema model was evaluated in this study. As shown in Fig. 2, in comparison with the non-steroidal anti-inflammatory drug indomethacin, MEO exhibited a significantly high anti-inflammatory activity in a dose-dependent manner. In addition, MEO reduced the edematous response by 5.77%, 7.37% and 30.24% at the dose of 200, 400 and 800 µg, respectively. The mouse ear plug weight was reduced by 16.79% after indomethacin treatment (dose 300 µg per ear).

Bottom Line: It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively.The results of this study may provide an experimental basis for further systematic research, rational development and clinical utilization of peppermint resources.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 200040, China.

ABSTRACT
The chemical composition, anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita (MEO) grown in China were investigated. Using GC-MS analysis, the chemical composition of MEO was characterized, showing that it was mainly composed of menthol, menthone and menthy acetate. MEO exhibited potent anti-inflammatory activities in a croton oil-induced mouse ear edema model. It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. The cytotoxic effect was assessed against four human cancer cells. MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively. In addition, MEO had moderate antioxidant activity. The results of this study may provide an experimental basis for further systematic research, rational development and clinical utilization of peppermint resources.

No MeSH data available.


Related in: MedlinePlus