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Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology.

Krishnamoorthi S, Perotti LE, Borgstrom NP, Ajijola OA, Frid A, Ponnaluri AV, Weiss JN, Qu Z, Klug WS, Ennis DB, Garfinkel A - PLoS ONE (2014)

Bottom Line: We solve the electrophysiology governing equations using the finite element method and compute both a 6-lead precordial electrocardiogram (ECG) and the activation wavefronts over time.We are particularly concerned with the validation of the various methods used in our model and, in this regard, propose a series of validation criteria that we consider essential.Among other components, we conclude that a Purkinje geometry with a high density of Purkinje muscle junctions covering the right and left ventricular endocardial surfaces as well as transmural and apex-to-base gradients in action potential characteristics are necessary to produce ECGs and time activation plots that agree with physiological observations.

View Article: PubMed Central - PubMed

Affiliation: Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, California, United States of America.

ABSTRACT
We describe a sequence of methods to produce a partial differential equation model of the electrical activation of the ventricles. In our framework, we incorporate the anatomy and cardiac microstructure obtained from magnetic resonance imaging and diffusion tensor imaging of a New Zealand White rabbit, the Purkinje structure and the Purkinje-muscle junctions, and an electrophysiologically accurate model of the ventricular myocytes and tissue, which includes transmural and apex-to-base gradients of action potential characteristics. We solve the electrophysiology governing equations using the finite element method and compute both a 6-lead precordial electrocardiogram (ECG) and the activation wavefronts over time. We are particularly concerned with the validation of the various methods used in our model and, in this regard, propose a series of validation criteria that we consider essential. These include producing a physiologically accurate ECG, a correct ventricular activation sequence, and the inducibility of ventricular fibrillation. Among other components, we conclude that a Purkinje geometry with a high density of Purkinje muscle junctions covering the right and left ventricular endocardial surfaces as well as transmural and apex-to-base gradients in action potential characteristics are necessary to produce ECGs and time activation plots that agree with physiological observations.

No MeSH data available.


Related in: MedlinePlus

Comparison of activation contour plots obtained using different models of activation.(A) Low PMJ density model, (B) high PMJ density model, and (C) instantaneous activation of the LV and RV endocardial surfaces.
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pone-0114494-g008: Comparison of activation contour plots obtained using different models of activation.(A) Low PMJ density model, (B) high PMJ density model, and (C) instantaneous activation of the LV and RV endocardial surfaces.

Mentions: Voltage space-time histories were computed using each of the three activation models — (i) low PMJ, (ii) high PMJ, and (iii) instantaneous endocardial activation — to activate conduction in the uniform mesh with element edges, and processed to construct activation maps (Fig. 8 - raw data available as supplementary material in S1 Dataset) by eqn. 10. Geolox tensor interpolation was used in all simulations. The low PMJ model differed from the experimental observations, producing an overall delay in the initial septal activation (). The complete activation of the myocardium was slower, with the basal region activated more than after stimulus of the AV node. The high PMJ model showed better agreement with experimental mapping results, showing synchronous activation of the LV and RV endocardium, and earlier septal activation (). The high PMJ model also yielded complete depolarization of the myocardium by about , consistent with experiments [36]. The activation movie corresponding to the high PMJ model is provided as supplementary material (S1 Movie).


Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology.

Krishnamoorthi S, Perotti LE, Borgstrom NP, Ajijola OA, Frid A, Ponnaluri AV, Weiss JN, Qu Z, Klug WS, Ennis DB, Garfinkel A - PLoS ONE (2014)

Comparison of activation contour plots obtained using different models of activation.(A) Low PMJ density model, (B) high PMJ density model, and (C) instantaneous activation of the LV and RV endocardial surfaces.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4262432&req=5

pone-0114494-g008: Comparison of activation contour plots obtained using different models of activation.(A) Low PMJ density model, (B) high PMJ density model, and (C) instantaneous activation of the LV and RV endocardial surfaces.
Mentions: Voltage space-time histories were computed using each of the three activation models — (i) low PMJ, (ii) high PMJ, and (iii) instantaneous endocardial activation — to activate conduction in the uniform mesh with element edges, and processed to construct activation maps (Fig. 8 - raw data available as supplementary material in S1 Dataset) by eqn. 10. Geolox tensor interpolation was used in all simulations. The low PMJ model differed from the experimental observations, producing an overall delay in the initial septal activation (). The complete activation of the myocardium was slower, with the basal region activated more than after stimulus of the AV node. The high PMJ model showed better agreement with experimental mapping results, showing synchronous activation of the LV and RV endocardium, and earlier septal activation (). The high PMJ model also yielded complete depolarization of the myocardium by about , consistent with experiments [36]. The activation movie corresponding to the high PMJ model is provided as supplementary material (S1 Movie).

Bottom Line: We solve the electrophysiology governing equations using the finite element method and compute both a 6-lead precordial electrocardiogram (ECG) and the activation wavefronts over time.We are particularly concerned with the validation of the various methods used in our model and, in this regard, propose a series of validation criteria that we consider essential.Among other components, we conclude that a Purkinje geometry with a high density of Purkinje muscle junctions covering the right and left ventricular endocardial surfaces as well as transmural and apex-to-base gradients in action potential characteristics are necessary to produce ECGs and time activation plots that agree with physiological observations.

View Article: PubMed Central - PubMed

Affiliation: Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, California, United States of America.

ABSTRACT
We describe a sequence of methods to produce a partial differential equation model of the electrical activation of the ventricles. In our framework, we incorporate the anatomy and cardiac microstructure obtained from magnetic resonance imaging and diffusion tensor imaging of a New Zealand White rabbit, the Purkinje structure and the Purkinje-muscle junctions, and an electrophysiologically accurate model of the ventricular myocytes and tissue, which includes transmural and apex-to-base gradients of action potential characteristics. We solve the electrophysiology governing equations using the finite element method and compute both a 6-lead precordial electrocardiogram (ECG) and the activation wavefronts over time. We are particularly concerned with the validation of the various methods used in our model and, in this regard, propose a series of validation criteria that we consider essential. These include producing a physiologically accurate ECG, a correct ventricular activation sequence, and the inducibility of ventricular fibrillation. Among other components, we conclude that a Purkinje geometry with a high density of Purkinje muscle junctions covering the right and left ventricular endocardial surfaces as well as transmural and apex-to-base gradients in action potential characteristics are necessary to produce ECGs and time activation plots that agree with physiological observations.

No MeSH data available.


Related in: MedlinePlus