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Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years.

Factor-Litvak P, Insel B, Calafat AM, Liu X, Perera F, Rauh VA, Whyatt RM - PLoS ONE (2014)

Bottom Line: Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers.Associations were unchanged after control for cognition at age 3 years.Because phthalate exposures are ubiquitous and concentrations seen here within the range previously observed among general populations, results are of public health significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.

ABSTRACT

Background: Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers. No study evaluated whether these associations persist into school age.

Methods: In a follow up of 328 inner-city mothers and their children, we measured prenatal urinary metabolites of di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP), di-isobutyl phthalate (DiBP), di-2-ethylhexyl phthalate and diethyl phthalate in late pregnancy. The Wechsler Intelligence Scale for Children, 4th edition was administered at child age 7 years and evaluates four areas of cognitive function associated with overall intelligence quotient (IQ).

Results: Child full-scale IQ was inversely associated with prenatal urinary metabolite concentrations of DnBP and DiBP: b = -2.69 (95% confidence interval [CI] = -4.33, -1.05) and b = -2.69 (95% CI = -4.22, -1.16) per log unit increase. Among children of mothers with the highest versus lowest quartile DnBP and DiBP metabolite concentrations, IQ was 6.7 (95% CI = 1.9, 11.4) and 7.6 (95% CI = 3.2, 12.1) points lower, respectively. Associations were unchanged after control for cognition at age 3 years. Significant inverse associations were also seen between maternal prenatal metabolite concentrations of DnBP and DiBP and child processing speed, perceptual reasoning and working memory; DiBP and child verbal comprehension; and BBzP and child perceptual reasoning.

Conclusion: Maternal prenatal urinary metabolite concentrations measured in late pregnancy of DnBP and DiBP are associated with deficits in children's intellectual development at age 7 years. Because phthalate exposures are ubiquitous and concentrations seen here within the range previously observed among general populations, results are of public health significance.

No MeSH data available.


Related in: MedlinePlus

Adjusted mean WISC-IV total score and subtest scored by lowest to highest quartile of maternal prenatal phthalate metabolite concentration (where q0 = lowest quartile, q4 = highest quartile, q2 and q3 intermediate quartiles).Means adjusted for urine specific gravity, maternal IQ, ethnicity, alcohol use during pregnancy, education, marital status, quality of the home environment (HOME score) and sex of child. *p<0.05, **p≤0.01.
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pone-0114003-g001: Adjusted mean WISC-IV total score and subtest scored by lowest to highest quartile of maternal prenatal phthalate metabolite concentration (where q0 = lowest quartile, q4 = highest quartile, q2 and q3 intermediate quartiles).Means adjusted for urine specific gravity, maternal IQ, ethnicity, alcohol use during pregnancy, education, marital status, quality of the home environment (HOME score) and sex of child. *p<0.05, **p≤0.01.

Mentions: Full scale IQ scores among children born to mothers with urinary MnBP and MiBP concentrations in the highest compared to the lowest quartiles were 6.6, 95% CI = (1.89, 11.41) and 7.6, 95% CI = (3.2, 12.1) points lower, respectively (Figure 1). Similar differences were found for the perceptual reasoning, processing speed and working memory scores. Children whose mother had the highest versus lowest concentration of MBzP and MiBP had significantly lower scores on perceptual reasoning (by 3.9 points) and verbal comprehension (by 4.4 points), respectively.


Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years.

Factor-Litvak P, Insel B, Calafat AM, Liu X, Perera F, Rauh VA, Whyatt RM - PLoS ONE (2014)

Adjusted mean WISC-IV total score and subtest scored by lowest to highest quartile of maternal prenatal phthalate metabolite concentration (where q0 = lowest quartile, q4 = highest quartile, q2 and q3 intermediate quartiles).Means adjusted for urine specific gravity, maternal IQ, ethnicity, alcohol use during pregnancy, education, marital status, quality of the home environment (HOME score) and sex of child. *p<0.05, **p≤0.01.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4262205&req=5

pone-0114003-g001: Adjusted mean WISC-IV total score and subtest scored by lowest to highest quartile of maternal prenatal phthalate metabolite concentration (where q0 = lowest quartile, q4 = highest quartile, q2 and q3 intermediate quartiles).Means adjusted for urine specific gravity, maternal IQ, ethnicity, alcohol use during pregnancy, education, marital status, quality of the home environment (HOME score) and sex of child. *p<0.05, **p≤0.01.
Mentions: Full scale IQ scores among children born to mothers with urinary MnBP and MiBP concentrations in the highest compared to the lowest quartiles were 6.6, 95% CI = (1.89, 11.41) and 7.6, 95% CI = (3.2, 12.1) points lower, respectively (Figure 1). Similar differences were found for the perceptual reasoning, processing speed and working memory scores. Children whose mother had the highest versus lowest concentration of MBzP and MiBP had significantly lower scores on perceptual reasoning (by 3.9 points) and verbal comprehension (by 4.4 points), respectively.

Bottom Line: Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers.Associations were unchanged after control for cognition at age 3 years.Because phthalate exposures are ubiquitous and concentrations seen here within the range previously observed among general populations, results are of public health significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.

ABSTRACT

Background: Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers. No study evaluated whether these associations persist into school age.

Methods: In a follow up of 328 inner-city mothers and their children, we measured prenatal urinary metabolites of di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP), di-isobutyl phthalate (DiBP), di-2-ethylhexyl phthalate and diethyl phthalate in late pregnancy. The Wechsler Intelligence Scale for Children, 4th edition was administered at child age 7 years and evaluates four areas of cognitive function associated with overall intelligence quotient (IQ).

Results: Child full-scale IQ was inversely associated with prenatal urinary metabolite concentrations of DnBP and DiBP: b = -2.69 (95% confidence interval [CI] = -4.33, -1.05) and b = -2.69 (95% CI = -4.22, -1.16) per log unit increase. Among children of mothers with the highest versus lowest quartile DnBP and DiBP metabolite concentrations, IQ was 6.7 (95% CI = 1.9, 11.4) and 7.6 (95% CI = 3.2, 12.1) points lower, respectively. Associations were unchanged after control for cognition at age 3 years. Significant inverse associations were also seen between maternal prenatal metabolite concentrations of DnBP and DiBP and child processing speed, perceptual reasoning and working memory; DiBP and child verbal comprehension; and BBzP and child perceptual reasoning.

Conclusion: Maternal prenatal urinary metabolite concentrations measured in late pregnancy of DnBP and DiBP are associated with deficits in children's intellectual development at age 7 years. Because phthalate exposures are ubiquitous and concentrations seen here within the range previously observed among general populations, results are of public health significance.

No MeSH data available.


Related in: MedlinePlus