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Red blood cell transfusion strategies and Maximum surgical blood ordering schedule.

Iyer SS, Shah J - Indian J Anaesth (2014)

Bottom Line: Blood transfusion is one of the practices that is in vogue because it expands blood volume and purportedly improves the oxygen carrying capacity.Institutional maximum surgical blood ordering schedule algorithm developed with data analysis and consensus of surgeons, anaesthesiologists and blood banks can reduce the overuse of blood.Search yielded a total of 1541 articles that were screened for clinical relevance for the purpose of this review.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care, Bharati Vidyapeeth University Medical College, Pune, Maharashtra, India.

ABSTRACT
Blood transfusion is one of the practices that is in vogue because it expands blood volume and purportedly improves the oxygen carrying capacity. Despite this supposed physiological benefit, paradoxically, both anaemia and transfusion are independently associated with organ injury and increased morbidity. Historically, transfusion was used to maintain blood haemoglobin concentration above 10 g/dL and a haematocrit above 30%. There is now a greater emphasis on interventions to reduce the use of transfusion as it is a scarce and expensive resource with many serious adverse effects. Institutional maximum surgical blood ordering schedule algorithm developed with data analysis and consensus of surgeons, anaesthesiologists and blood banks can reduce the overuse of blood. A PubMed search was performed with search words/combination of words 'erythrocyte transfusion, adverse effects, economics, mortality, therapy, therapeutic use and utilisation'. Search yielded a total of 1541 articles that were screened for clinical relevance for the purpose of this review.

No MeSH data available.


Related in: MedlinePlus

Oxygen delivery oxygen consumption relationship
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Figure 1: Oxygen delivery oxygen consumption relationship

Mentions: Oxygen extraction ratio is the ratio of VO2 /DO2 and is normally around 20-30%, allowing a significant safety margin. The rate of delivery normally exceeds consumption by a factor of four. Thus, if intravascular volume is maintained while bleeding and cardiovascular status is not impaired, DO2 will remain adequate until the haematocrit falls below 10%. This is due to a compensatory increase in cardiac output, the rightward shift of the oxygen-Hb dissociation curve and increased oxygen extraction [Figure 1].


Red blood cell transfusion strategies and Maximum surgical blood ordering schedule.

Iyer SS, Shah J - Indian J Anaesth (2014)

Oxygen delivery oxygen consumption relationship
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260304&req=5

Figure 1: Oxygen delivery oxygen consumption relationship
Mentions: Oxygen extraction ratio is the ratio of VO2 /DO2 and is normally around 20-30%, allowing a significant safety margin. The rate of delivery normally exceeds consumption by a factor of four. Thus, if intravascular volume is maintained while bleeding and cardiovascular status is not impaired, DO2 will remain adequate until the haematocrit falls below 10%. This is due to a compensatory increase in cardiac output, the rightward shift of the oxygen-Hb dissociation curve and increased oxygen extraction [Figure 1].

Bottom Line: Blood transfusion is one of the practices that is in vogue because it expands blood volume and purportedly improves the oxygen carrying capacity.Institutional maximum surgical blood ordering schedule algorithm developed with data analysis and consensus of surgeons, anaesthesiologists and blood banks can reduce the overuse of blood.Search yielded a total of 1541 articles that were screened for clinical relevance for the purpose of this review.

View Article: PubMed Central - PubMed

Affiliation: Department of Critical Care, Bharati Vidyapeeth University Medical College, Pune, Maharashtra, India.

ABSTRACT
Blood transfusion is one of the practices that is in vogue because it expands blood volume and purportedly improves the oxygen carrying capacity. Despite this supposed physiological benefit, paradoxically, both anaemia and transfusion are independently associated with organ injury and increased morbidity. Historically, transfusion was used to maintain blood haemoglobin concentration above 10 g/dL and a haematocrit above 30%. There is now a greater emphasis on interventions to reduce the use of transfusion as it is a scarce and expensive resource with many serious adverse effects. Institutional maximum surgical blood ordering schedule algorithm developed with data analysis and consensus of surgeons, anaesthesiologists and blood banks can reduce the overuse of blood. A PubMed search was performed with search words/combination of words 'erythrocyte transfusion, adverse effects, economics, mortality, therapy, therapeutic use and utilisation'. Search yielded a total of 1541 articles that were screened for clinical relevance for the purpose of this review.

No MeSH data available.


Related in: MedlinePlus