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Overview of the coagulation system.

Palta S, Saroa R, Palta A - Indian J Anaesth (2014)

Bottom Line: Coagulation is a dynamic process and the understanding of the blood coagulation system has evolved over the recent years in anaesthetic practice.Although the traditional classification of the coagulation system into extrinsic and intrinsic pathway is still valid, the newer insights into coagulation provide more authentic description of the same.Normal coagulation pathway represents a balance between the pro coagulant pathway that is responsible for clot formation and the mechanisms that inhibit the same beyond the injury site.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Intensive Care, Government Medical College and Hospital, Chandigarh, India.

ABSTRACT
Coagulation is a dynamic process and the understanding of the blood coagulation system has evolved over the recent years in anaesthetic practice. Although the traditional classification of the coagulation system into extrinsic and intrinsic pathway is still valid, the newer insights into coagulation provide more authentic description of the same. Normal coagulation pathway represents a balance between the pro coagulant pathway that is responsible for clot formation and the mechanisms that inhibit the same beyond the injury site. Imbalance of the coagulation system may occur in the perioperative period or during critical illness, which may be secondary to numerous factors leading to a tendency of either thrombosis or bleeding. A systematic search of literature on PubMed with MeSH terms 'coagulation system, haemostasis and anaesthesia revealed twenty eight related clinical trials and review articles in last 10 years. Since the balance of the coagulation system may tilt towards bleeding and thrombosis in many situations, it is mandatory for the clinicians to understand physiologic basis of haemostasis in order to diagnose and manage the abnormalities of the coagulation process and to interpret the diagnostic tests done for the same.

No MeSH data available.


Related in: MedlinePlus

Current concept of coagulation (initiation phase)
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Figure 2: Current concept of coagulation (initiation phase)

Mentions: It occurs by expression of TF in damaged vessel which binds factor VIIa to activate factor IX and factor X. This activation of factor IX by TF-VIIa complex serves as the bridge between classical extrinsic and intrinsic pathways. Factor Xa then binds to factor II to form thrombin (factor IIa). Thrombin generation through this reaction is not robust and can be effectively terminated by TF pathway inhibitor [Figure 2].


Overview of the coagulation system.

Palta S, Saroa R, Palta A - Indian J Anaesth (2014)

Current concept of coagulation (initiation phase)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260295&req=5

Figure 2: Current concept of coagulation (initiation phase)
Mentions: It occurs by expression of TF in damaged vessel which binds factor VIIa to activate factor IX and factor X. This activation of factor IX by TF-VIIa complex serves as the bridge between classical extrinsic and intrinsic pathways. Factor Xa then binds to factor II to form thrombin (factor IIa). Thrombin generation through this reaction is not robust and can be effectively terminated by TF pathway inhibitor [Figure 2].

Bottom Line: Coagulation is a dynamic process and the understanding of the blood coagulation system has evolved over the recent years in anaesthetic practice.Although the traditional classification of the coagulation system into extrinsic and intrinsic pathway is still valid, the newer insights into coagulation provide more authentic description of the same.Normal coagulation pathway represents a balance between the pro coagulant pathway that is responsible for clot formation and the mechanisms that inhibit the same beyond the injury site.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Intensive Care, Government Medical College and Hospital, Chandigarh, India.

ABSTRACT
Coagulation is a dynamic process and the understanding of the blood coagulation system has evolved over the recent years in anaesthetic practice. Although the traditional classification of the coagulation system into extrinsic and intrinsic pathway is still valid, the newer insights into coagulation provide more authentic description of the same. Normal coagulation pathway represents a balance between the pro coagulant pathway that is responsible for clot formation and the mechanisms that inhibit the same beyond the injury site. Imbalance of the coagulation system may occur in the perioperative period or during critical illness, which may be secondary to numerous factors leading to a tendency of either thrombosis or bleeding. A systematic search of literature on PubMed with MeSH terms 'coagulation system, haemostasis and anaesthesia revealed twenty eight related clinical trials and review articles in last 10 years. Since the balance of the coagulation system may tilt towards bleeding and thrombosis in many situations, it is mandatory for the clinicians to understand physiologic basis of haemostasis in order to diagnose and manage the abnormalities of the coagulation process and to interpret the diagnostic tests done for the same.

No MeSH data available.


Related in: MedlinePlus