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Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy.

Sachan R, Patel M, Gaurav A, Gangwar R, Sachan P - Adv Biomed Res (2014)

Bottom Line: Mean serum NGAL value in patients with oliguria was significantly higher when compared with non-oliguric patients (P < 0.001).Sensitivity and specificity of serum NGAL using a cut-off value of 545 pg/ml, for the diagnosis of HDP, was 97.89% and 93.55% respectively, using 95% confidence interval.Between the two groups, we found that serum NGAL had a positive correlation with disease severity and better sensitivity and specificity in the evaluation of HDP.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT

Background: Vascular endothelial dysfunction is considered central to the pathogenesis of hypertensive disorders of pregnancy (HDP). Serum level of neutrophil gelatinase-associated lipocalin (NGAL) is closely related to endothelial injury. The aim of this study was to examine the correlation of serum NGAL with disease severity in HDP.

Materials and methods: This prospective case-control study was carried out for one year. After informed consent, ethical clearance, total 1,850 pregnant women were screened. Analysis was performed on 142 cases of HDP and 31 healthy controls. Quantitative measurement of serum NGAL levels was done by the enzyme linked immunosorbent assay (ELISA) technique, by using sandwich ELISA kit.

Results: Mean serum NGAL value in patients with oliguria was significantly higher when compared with non-oliguric patients (P < 0.001). Serum NGAL had a positive correlation with systolic blood pressure (r ~ 0.5973), diastolic blood pressure (r ~ 0.6195), blood urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878). Sensitivity and specificity of serum NGAL using a cut-off value of 545 pg/ml, for the diagnosis of HDP, was 97.89% and 93.55% respectively, using 95% confidence interval.

Conclusion: Between the two groups, we found that serum NGAL had a positive correlation with disease severity and better sensitivity and specificity in the evaluation of HDP.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic curve
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Figure 1: Receiver operating characteristic curve

Mentions: The Spearman's rank correlation coefficient shows that serum NGAL had a positive correlation with SBP (r ~ 0.5973), DBP (r ~ 0.6195), serum urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878) and it also had a positive correlation with serum bilirubin (r ~ 0.4637) and liver enzymes. Positive correlation coefficient of these parameters with serum NGAL implies that serum NGAL increases with an increase in the above mentioned parameters. Serum NGAL has a negative correlation with birth weight of baby; mean serum NGAL increases with a decrease in birth weight of the baby indicate intrauterine growth retardation [Figure 1].


Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy.

Sachan R, Patel M, Gaurav A, Gangwar R, Sachan P - Adv Biomed Res (2014)

Receiver operating characteristic curve
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260273&req=5

Figure 1: Receiver operating characteristic curve
Mentions: The Spearman's rank correlation coefficient shows that serum NGAL had a positive correlation with SBP (r ~ 0.5973), DBP (r ~ 0.6195), serum urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878) and it also had a positive correlation with serum bilirubin (r ~ 0.4637) and liver enzymes. Positive correlation coefficient of these parameters with serum NGAL implies that serum NGAL increases with an increase in the above mentioned parameters. Serum NGAL has a negative correlation with birth weight of baby; mean serum NGAL increases with a decrease in birth weight of the baby indicate intrauterine growth retardation [Figure 1].

Bottom Line: Mean serum NGAL value in patients with oliguria was significantly higher when compared with non-oliguric patients (P < 0.001).Sensitivity and specificity of serum NGAL using a cut-off value of 545 pg/ml, for the diagnosis of HDP, was 97.89% and 93.55% respectively, using 95% confidence interval.Between the two groups, we found that serum NGAL had a positive correlation with disease severity and better sensitivity and specificity in the evaluation of HDP.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT

Background: Vascular endothelial dysfunction is considered central to the pathogenesis of hypertensive disorders of pregnancy (HDP). Serum level of neutrophil gelatinase-associated lipocalin (NGAL) is closely related to endothelial injury. The aim of this study was to examine the correlation of serum NGAL with disease severity in HDP.

Materials and methods: This prospective case-control study was carried out for one year. After informed consent, ethical clearance, total 1,850 pregnant women were screened. Analysis was performed on 142 cases of HDP and 31 healthy controls. Quantitative measurement of serum NGAL levels was done by the enzyme linked immunosorbent assay (ELISA) technique, by using sandwich ELISA kit.

Results: Mean serum NGAL value in patients with oliguria was significantly higher when compared with non-oliguric patients (P < 0.001). Serum NGAL had a positive correlation with systolic blood pressure (r ~ 0.5973), diastolic blood pressure (r ~ 0.6195), blood urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878). Sensitivity and specificity of serum NGAL using a cut-off value of 545 pg/ml, for the diagnosis of HDP, was 97.89% and 93.55% respectively, using 95% confidence interval.

Conclusion: Between the two groups, we found that serum NGAL had a positive correlation with disease severity and better sensitivity and specificity in the evaluation of HDP.

No MeSH data available.


Related in: MedlinePlus