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A novel pathogenic classification of cancers.

Sonnenschein C, Davis B, Soto AM - Cancer Cell Int. (2014)

Bottom Line: According to contemporary epidemiological and experimental evidence, we propose a novel classification of cancers based on pathogenesis instead of classifications based on histological appearance of cancer.This new scheme first defines cancers as either 1. inborn errors of development or 2. sporadic ones, and then sub-defines the former into 1A. inborn inherited errors of development, being those due to mutations contributed by one or both parents' gametes to the developing conceptus, and 1B. inborn induced errors of development when the malformations and/or cancers are due to environmental carcinogenic exposure during pregnancy.It is anticipated that the origin of an increasing number of so-called sporadic cancers will turn out to be linked to the inborn induced errors of development group.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111 USA.

ABSTRACT
According to contemporary epidemiological and experimental evidence, we propose a novel classification of cancers based on pathogenesis instead of classifications based on histological appearance of cancer. This new scheme first defines cancers as either 1. inborn errors of development or 2. sporadic ones, and then sub-defines the former into 1A. inborn inherited errors of development, being those due to mutations contributed by one or both parents' gametes to the developing conceptus, and 1B. inborn induced errors of development when the malformations and/or cancers are due to environmental carcinogenic exposure during pregnancy. It is anticipated that the origin of an increasing number of so-called sporadic cancers will turn out to be linked to the inborn induced errors of development group.

No MeSH data available.


Related in: MedlinePlus

Novel pathogenetic classification of neoplasia. This classification distinguishes 2 main types of neoplasia as inborn errors of development (A) and sporadic cancers (B). A is further classified into inborn errors of development that may be either inherited (a) or induced (b).
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Fig1: Novel pathogenetic classification of neoplasia. This classification distinguishes 2 main types of neoplasia as inborn errors of development (A) and sporadic cancers (B). A is further classified into inborn errors of development that may be either inherited (a) or induced (b).

Mentions: In FigureĀ 1, we outline our proposed novel etiopathogenic classification of cancers. It is comprised of two main groups of tumors, namely, 1. Inborn errors of development. Within this group, we identify 2 sub-groups of neoplasms. First, there are 1A. Inborninheritederrors of development - the result of a process initiated by a germ-line mutation(s) in the genome of one or both gametes (sperm and/or ovum). The mutated genome of the resulting zygote will endow all the cells in the morphogenetic fields of the developing organism with such a genomic mutation(s). The altered expression of these mutated genes could take place either during organogenesis, tissue remodeling and/or repair. This provides a temporal-dependent dimension to the carcinogenic process. Examples of this variety of inborn error of development include retinoblastoma, Gorlin syndrome, xeroderma pigmentosa, BRCA-1 and-2 neoplasia, and many others (for a comprehensive listing and description of these tumors see [41,42]).Figure 1


A novel pathogenic classification of cancers.

Sonnenschein C, Davis B, Soto AM - Cancer Cell Int. (2014)

Novel pathogenetic classification of neoplasia. This classification distinguishes 2 main types of neoplasia as inborn errors of development (A) and sporadic cancers (B). A is further classified into inborn errors of development that may be either inherited (a) or induced (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4260242&req=5

Fig1: Novel pathogenetic classification of neoplasia. This classification distinguishes 2 main types of neoplasia as inborn errors of development (A) and sporadic cancers (B). A is further classified into inborn errors of development that may be either inherited (a) or induced (b).
Mentions: In FigureĀ 1, we outline our proposed novel etiopathogenic classification of cancers. It is comprised of two main groups of tumors, namely, 1. Inborn errors of development. Within this group, we identify 2 sub-groups of neoplasms. First, there are 1A. Inborninheritederrors of development - the result of a process initiated by a germ-line mutation(s) in the genome of one or both gametes (sperm and/or ovum). The mutated genome of the resulting zygote will endow all the cells in the morphogenetic fields of the developing organism with such a genomic mutation(s). The altered expression of these mutated genes could take place either during organogenesis, tissue remodeling and/or repair. This provides a temporal-dependent dimension to the carcinogenic process. Examples of this variety of inborn error of development include retinoblastoma, Gorlin syndrome, xeroderma pigmentosa, BRCA-1 and-2 neoplasia, and many others (for a comprehensive listing and description of these tumors see [41,42]).Figure 1

Bottom Line: According to contemporary epidemiological and experimental evidence, we propose a novel classification of cancers based on pathogenesis instead of classifications based on histological appearance of cancer.This new scheme first defines cancers as either 1. inborn errors of development or 2. sporadic ones, and then sub-defines the former into 1A. inborn inherited errors of development, being those due to mutations contributed by one or both parents' gametes to the developing conceptus, and 1B. inborn induced errors of development when the malformations and/or cancers are due to environmental carcinogenic exposure during pregnancy.It is anticipated that the origin of an increasing number of so-called sporadic cancers will turn out to be linked to the inborn induced errors of development group.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111 USA.

ABSTRACT
According to contemporary epidemiological and experimental evidence, we propose a novel classification of cancers based on pathogenesis instead of classifications based on histological appearance of cancer. This new scheme first defines cancers as either 1. inborn errors of development or 2. sporadic ones, and then sub-defines the former into 1A. inborn inherited errors of development, being those due to mutations contributed by one or both parents' gametes to the developing conceptus, and 1B. inborn induced errors of development when the malformations and/or cancers are due to environmental carcinogenic exposure during pregnancy. It is anticipated that the origin of an increasing number of so-called sporadic cancers will turn out to be linked to the inborn induced errors of development group.

No MeSH data available.


Related in: MedlinePlus