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Ultrasensitive non-enzymatic glucose sensor based on three-dimensional network of ZnO-CuO hierarchical nanocomposites by electrospinning.

Zhou C, Xu L, Song J, Xing R, Xu S, Liu D, Song H - Sci Rep (2014)

Bottom Line: Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes.Moreover, a good synergetic effect between CuO and ZnO was confirmed.The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

ABSTRACT
Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes. The structural characterization revealed that the ZnO-CuO HNCs were composed of the ZnO and CuO mixed NWs trunk (~200 nm), whose outer surface was attached with small CuO nanoparticles (NPs). Moreover, a good synergetic effect between CuO and ZnO was confirmed. The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs. At an applied potential of + 0.7 V, the optimum ZnO-CuO HNCs electrode presented a high sensitivity of 3066.4 μAmM(-1)cm(-2), the linear range up to 1.6 mM, and low practical detection limit of 0.21 μM. It also showed outstanding long term stability, good reproducibility, excellent selectivity and accurate measurement in real serum sample. The formation of special hierarchical heterojunction and the well-constructed 3D structure were the main reasons for the enhanced nonenzymatic biosensing behavior.

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Reaction mechanism of 3D porous ZnO–CuO HNCs electrodes.(the image of the flask are painting according to the model in our experiment by Lin Xu, one of the auther of this article).
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f6: Reaction mechanism of 3D porous ZnO–CuO HNCs electrodes.(the image of the flask are painting according to the model in our experiment by Lin Xu, one of the auther of this article).

Mentions: The cyclic voltammetry profiles of 3D porous ZnO–CuO HNCs electrodes as well as 3D mixed ZnO/CuO NWs, pure CuO NWs and ZnO NWs electrodes in 30 mL 0.1 M NaOH solution without and with 5 mM glucose were studied (Fig. 5). The corresponding nonenzymatic response process to glucose is as depicted in Fig. 6. The Cu(II)/Cu(III) redox couple in the NaOH solution under the special potential region is the essential factor for nonenzymatic electrochemical glucose detection. When in blank NaOH solution, obvious reduction peaks around +0.7 V can be observed of all the electrodes (except pure ZnO NWs electrode) in our work which corresponding to the Cu(II)/Cu(III) redox couple according to previous studies32, the reaction process can be depicted as:


Ultrasensitive non-enzymatic glucose sensor based on three-dimensional network of ZnO-CuO hierarchical nanocomposites by electrospinning.

Zhou C, Xu L, Song J, Xing R, Xu S, Liu D, Song H - Sci Rep (2014)

Reaction mechanism of 3D porous ZnO–CuO HNCs electrodes.(the image of the flask are painting according to the model in our experiment by Lin Xu, one of the auther of this article).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260231&req=5

f6: Reaction mechanism of 3D porous ZnO–CuO HNCs electrodes.(the image of the flask are painting according to the model in our experiment by Lin Xu, one of the auther of this article).
Mentions: The cyclic voltammetry profiles of 3D porous ZnO–CuO HNCs electrodes as well as 3D mixed ZnO/CuO NWs, pure CuO NWs and ZnO NWs electrodes in 30 mL 0.1 M NaOH solution without and with 5 mM glucose were studied (Fig. 5). The corresponding nonenzymatic response process to glucose is as depicted in Fig. 6. The Cu(II)/Cu(III) redox couple in the NaOH solution under the special potential region is the essential factor for nonenzymatic electrochemical glucose detection. When in blank NaOH solution, obvious reduction peaks around +0.7 V can be observed of all the electrodes (except pure ZnO NWs electrode) in our work which corresponding to the Cu(II)/Cu(III) redox couple according to previous studies32, the reaction process can be depicted as:

Bottom Line: Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes.Moreover, a good synergetic effect between CuO and ZnO was confirmed.The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

ABSTRACT
Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes. The structural characterization revealed that the ZnO-CuO HNCs were composed of the ZnO and CuO mixed NWs trunk (~200 nm), whose outer surface was attached with small CuO nanoparticles (NPs). Moreover, a good synergetic effect between CuO and ZnO was confirmed. The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs. At an applied potential of + 0.7 V, the optimum ZnO-CuO HNCs electrode presented a high sensitivity of 3066.4 μAmM(-1)cm(-2), the linear range up to 1.6 mM, and low practical detection limit of 0.21 μM. It also showed outstanding long term stability, good reproducibility, excellent selectivity and accurate measurement in real serum sample. The formation of special hierarchical heterojunction and the well-constructed 3D structure were the main reasons for the enhanced nonenzymatic biosensing behavior.

Show MeSH