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Ultrasensitive non-enzymatic glucose sensor based on three-dimensional network of ZnO-CuO hierarchical nanocomposites by electrospinning.

Zhou C, Xu L, Song J, Xing R, Xu S, Liu D, Song H - Sci Rep (2014)

Bottom Line: Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes.Moreover, a good synergetic effect between CuO and ZnO was confirmed.The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

ABSTRACT
Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes. The structural characterization revealed that the ZnO-CuO HNCs were composed of the ZnO and CuO mixed NWs trunk (~200 nm), whose outer surface was attached with small CuO nanoparticles (NPs). Moreover, a good synergetic effect between CuO and ZnO was confirmed. The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs. At an applied potential of + 0.7 V, the optimum ZnO-CuO HNCs electrode presented a high sensitivity of 3066.4 μAmM(-1)cm(-2), the linear range up to 1.6 mM, and low practical detection limit of 0.21 μM. It also showed outstanding long term stability, good reproducibility, excellent selectivity and accurate measurement in real serum sample. The formation of special hierarchical heterojunction and the well-constructed 3D structure were the main reasons for the enhanced nonenzymatic biosensing behavior.

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(a) TEM image and (b) HR-TEM image of ZnO–CuO HNCs. (c), (d), and (e), EDX elemental mapping images of O, Cu, and, Zn in the ZnO–CuO HNCs sample taken from the box of (a).
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f3: (a) TEM image and (b) HR-TEM image of ZnO–CuO HNCs. (c), (d), and (e), EDX elemental mapping images of O, Cu, and, Zn in the ZnO–CuO HNCs sample taken from the box of (a).

Mentions: The heteroarchitecture of the ZnO–CuO HNCs can be further confirmed from transmission electron microscopy (TEM) image (Fig. 3a). The as marked interplanar distances of the fringes are 0.232 nm and 0.252 nm, corresponding to the (111) face of CuO and the (101) face of ZnO, respectively (Fig. 3b). Further, as shown in energy dispersive X-ray (EDX) mappings (Fig. 3c–e), the distribution of Cu element is similar with that of O, which shows a hierarchical structure with uniform and discontinuous NPs on the surface of NWs trunk. The distribution of Zn element is much more homogeneous, which only shows a NWs structure. This demonstrates that the NWs trunk is composed of uniform mixture of CuO and ZnO, and the NPs dispersed on the outer surface of the NWs trunk are mainly composed of CuO.


Ultrasensitive non-enzymatic glucose sensor based on three-dimensional network of ZnO-CuO hierarchical nanocomposites by electrospinning.

Zhou C, Xu L, Song J, Xing R, Xu S, Liu D, Song H - Sci Rep (2014)

(a) TEM image and (b) HR-TEM image of ZnO–CuO HNCs. (c), (d), and (e), EDX elemental mapping images of O, Cu, and, Zn in the ZnO–CuO HNCs sample taken from the box of (a).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260231&req=5

f3: (a) TEM image and (b) HR-TEM image of ZnO–CuO HNCs. (c), (d), and (e), EDX elemental mapping images of O, Cu, and, Zn in the ZnO–CuO HNCs sample taken from the box of (a).
Mentions: The heteroarchitecture of the ZnO–CuO HNCs can be further confirmed from transmission electron microscopy (TEM) image (Fig. 3a). The as marked interplanar distances of the fringes are 0.232 nm and 0.252 nm, corresponding to the (111) face of CuO and the (101) face of ZnO, respectively (Fig. 3b). Further, as shown in energy dispersive X-ray (EDX) mappings (Fig. 3c–e), the distribution of Cu element is similar with that of O, which shows a hierarchical structure with uniform and discontinuous NPs on the surface of NWs trunk. The distribution of Zn element is much more homogeneous, which only shows a NWs structure. This demonstrates that the NWs trunk is composed of uniform mixture of CuO and ZnO, and the NPs dispersed on the outer surface of the NWs trunk are mainly composed of CuO.

Bottom Line: Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes.Moreover, a good synergetic effect between CuO and ZnO was confirmed.The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

ABSTRACT
Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes. The structural characterization revealed that the ZnO-CuO HNCs were composed of the ZnO and CuO mixed NWs trunk (~200 nm), whose outer surface was attached with small CuO nanoparticles (NPs). Moreover, a good synergetic effect between CuO and ZnO was confirmed. The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs. At an applied potential of + 0.7 V, the optimum ZnO-CuO HNCs electrode presented a high sensitivity of 3066.4 μAmM(-1)cm(-2), the linear range up to 1.6 mM, and low practical detection limit of 0.21 μM. It also showed outstanding long term stability, good reproducibility, excellent selectivity and accurate measurement in real serum sample. The formation of special hierarchical heterojunction and the well-constructed 3D structure were the main reasons for the enhanced nonenzymatic biosensing behavior.

Show MeSH