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Ultrasensitive non-enzymatic glucose sensor based on three-dimensional network of ZnO-CuO hierarchical nanocomposites by electrospinning.

Zhou C, Xu L, Song J, Xing R, Xu S, Liu D, Song H - Sci Rep (2014)

Bottom Line: Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes.Moreover, a good synergetic effect between CuO and ZnO was confirmed.The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

ABSTRACT
Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes. The structural characterization revealed that the ZnO-CuO HNCs were composed of the ZnO and CuO mixed NWs trunk (~200 nm), whose outer surface was attached with small CuO nanoparticles (NPs). Moreover, a good synergetic effect between CuO and ZnO was confirmed. The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs. At an applied potential of + 0.7 V, the optimum ZnO-CuO HNCs electrode presented a high sensitivity of 3066.4 μAmM(-1)cm(-2), the linear range up to 1.6 mM, and low practical detection limit of 0.21 μM. It also showed outstanding long term stability, good reproducibility, excellent selectivity and accurate measurement in real serum sample. The formation of special hierarchical heterojunction and the well-constructed 3D structure were the main reasons for the enhanced nonenzymatic biosensing behavior.

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(a) and (b) typical SEM image of 3D porous ZnO–CuO HNCs electrode (20 min) on the surface of FTO. (c) and (d) the low- and high-magnification cross section SEM images of (b). (e) The SEM image of 3D pure CuO NWs electrode. The inset of (e) is its high-magnification SEM image. (f) The SEM image of 3D mixed ZnO/CuO NWs and its inset is high-magnification SEM image.
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f2: (a) and (b) typical SEM image of 3D porous ZnO–CuO HNCs electrode (20 min) on the surface of FTO. (c) and (d) the low- and high-magnification cross section SEM images of (b). (e) The SEM image of 3D pure CuO NWs electrode. The inset of (e) is its high-magnification SEM image. (f) The SEM image of 3D mixed ZnO/CuO NWs and its inset is high-magnification SEM image.

Mentions: Fig. 2a and 2b show the scanning electron microscopy (SEM) images of the as-fabricated 3D porous ZnO–CuO HNCs. These randomly oriented HNCs all have uniform and long continuous surface in a large scale. In each HNCs structure there are some small NPs (~20 nm in diameter) attached randomly on the surface of the NWs, whose outer diameters are ~200 nm. Fig. 2c and 2d are the low- and high-magnification cross section SEM images of the 3D ZnO–CuO HNCs electrode (20 min). As is observed that the uniform 3D film is formed with thickness of 13.5 ± 0.3 µm and the hierarchical structure remains after hot pressing. Besides, the porous structure in the thickness dimension can be clearly identified, which is an obvious evidence of the effective formation of 3D porous electrode. Note that all the 3D porous ZnO–CuO HNCs electrodes have the similar planar morphology, but with different thicknesses as shown in Fig. S1a-f. In detail, the corresponding thicknesses are 5.3 ± 0.3 µm for 10 min, 7.8 ± 0.4 µm for 15 min, and 18.0 ± 0.5 µm for 25 min coelectrospinning time. Fig. 2e and Fig. 2f shows the planar morphology of 3D pure CuO NWs and 3D mixed ZnO/CuO NWs electrodes for compare, the average diameter are both ~200 nm and the thickness of corresponding 3D electrodes (not shown) are also comparable with that of the 3D ZnO–CuO HNCs electrode (20 min). The morphology of 3D pure ZnO NWs are also provided for comparing as shown in Fig. S1g and h, which exhibits much smoother surface than the other samples, thus the thickness of corresponding 3D electrodes (20 min) is relatively thick (11.1 ± 0.5 µm).


Ultrasensitive non-enzymatic glucose sensor based on three-dimensional network of ZnO-CuO hierarchical nanocomposites by electrospinning.

Zhou C, Xu L, Song J, Xing R, Xu S, Liu D, Song H - Sci Rep (2014)

(a) and (b) typical SEM image of 3D porous ZnO–CuO HNCs electrode (20 min) on the surface of FTO. (c) and (d) the low- and high-magnification cross section SEM images of (b). (e) The SEM image of 3D pure CuO NWs electrode. The inset of (e) is its high-magnification SEM image. (f) The SEM image of 3D mixed ZnO/CuO NWs and its inset is high-magnification SEM image.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260231&req=5

f2: (a) and (b) typical SEM image of 3D porous ZnO–CuO HNCs electrode (20 min) on the surface of FTO. (c) and (d) the low- and high-magnification cross section SEM images of (b). (e) The SEM image of 3D pure CuO NWs electrode. The inset of (e) is its high-magnification SEM image. (f) The SEM image of 3D mixed ZnO/CuO NWs and its inset is high-magnification SEM image.
Mentions: Fig. 2a and 2b show the scanning electron microscopy (SEM) images of the as-fabricated 3D porous ZnO–CuO HNCs. These randomly oriented HNCs all have uniform and long continuous surface in a large scale. In each HNCs structure there are some small NPs (~20 nm in diameter) attached randomly on the surface of the NWs, whose outer diameters are ~200 nm. Fig. 2c and 2d are the low- and high-magnification cross section SEM images of the 3D ZnO–CuO HNCs electrode (20 min). As is observed that the uniform 3D film is formed with thickness of 13.5 ± 0.3 µm and the hierarchical structure remains after hot pressing. Besides, the porous structure in the thickness dimension can be clearly identified, which is an obvious evidence of the effective formation of 3D porous electrode. Note that all the 3D porous ZnO–CuO HNCs electrodes have the similar planar morphology, but with different thicknesses as shown in Fig. S1a-f. In detail, the corresponding thicknesses are 5.3 ± 0.3 µm for 10 min, 7.8 ± 0.4 µm for 15 min, and 18.0 ± 0.5 µm for 25 min coelectrospinning time. Fig. 2e and Fig. 2f shows the planar morphology of 3D pure CuO NWs and 3D mixed ZnO/CuO NWs electrodes for compare, the average diameter are both ~200 nm and the thickness of corresponding 3D electrodes (not shown) are also comparable with that of the 3D ZnO–CuO HNCs electrode (20 min). The morphology of 3D pure ZnO NWs are also provided for comparing as shown in Fig. S1g and h, which exhibits much smoother surface than the other samples, thus the thickness of corresponding 3D electrodes (20 min) is relatively thick (11.1 ± 0.5 µm).

Bottom Line: Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes.Moreover, a good synergetic effect between CuO and ZnO was confirmed.The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

ABSTRACT
Three-dimensional (3D) porous ZnO-CuO hierarchical nanocomposites (HNCs) nonenzymatic glucose electrodes with different thicknesses were fabricated by coelectrospinning and compared with 3D mixed ZnO/CuO nanowires (NWs) and pure CuO NWs electrodes. The structural characterization revealed that the ZnO-CuO HNCs were composed of the ZnO and CuO mixed NWs trunk (~200 nm), whose outer surface was attached with small CuO nanoparticles (NPs). Moreover, a good synergetic effect between CuO and ZnO was confirmed. The nonenzymatic biosensing properties of as prepared 3D porous electrodes based on fluorine doped tin oxide (FTO) were studied and the results indicated that the sensing properties of 3D porous ZnO-CuO HNCs electrodes were significantly improved and depended strongly on the thickness of the HNCs. At an applied potential of + 0.7 V, the optimum ZnO-CuO HNCs electrode presented a high sensitivity of 3066.4 μAmM(-1)cm(-2), the linear range up to 1.6 mM, and low practical detection limit of 0.21 μM. It also showed outstanding long term stability, good reproducibility, excellent selectivity and accurate measurement in real serum sample. The formation of special hierarchical heterojunction and the well-constructed 3D structure were the main reasons for the enhanced nonenzymatic biosensing behavior.

Show MeSH