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Steady-state BOLD response modulates low frequency neural oscillations.

Wang YF, Liu F, Long ZL, Duan XJ, Cui Q, Yan JH, Chen HF - Sci Rep (2014)

Bottom Line: Specifically, the harmonic phenomenon of SSBR was task-related and independent of the neurovascular coupling.These findings suggested that the SSBRs represent non-linear neural oscillations but not brain activations.In comparison with the conventional general linear model, the SSBRs provide us novel insights into the non-linear brain activities, low frequency neural oscillations, and neuroplasticity of brain training and cognitive activities.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.

ABSTRACT
Neural oscillations are the intrinsic characteristics of brain activities. Traditional electrophysiological techniques (e.g., the steady-state evoked potential, SSEP) have provided important insights into the mechanisms of neural oscillations in the high frequency ranges (>1 Hz). However, the neural oscillations within the low frequency ranges (<1 Hz) and deep brain areas are rarely examined. Based on the advantages of the low frequency blood oxygen level dependent (BOLD) fluctuations, we expected that the steady-state BOLD responses (SSBRs) would be elicited and modulate low frequency neural oscillations. Twenty six participants completed a simple reaction time task with the constant stimuli frequencies of 0.0625 Hz and 0.125 Hz. Power analysis and hemodynamic response function deconvolution method were used to extract SSBRs and recover neural level signals. The SSEP-like waveforms were observed at the whole brain level and at several task-related brain regions. Specifically, the harmonic phenomenon of SSBR was task-related and independent of the neurovascular coupling. These findings suggested that the SSBRs represent non-linear neural oscillations but not brain activations. In comparison with the conventional general linear model, the SSBRs provide us novel insights into the non-linear brain activities, low frequency neural oscillations, and neuroplasticity of brain training and cognitive activities.

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Related in: MedlinePlus

The regional SSBRs evoked by LF and HF stimuli.The distribution of SSBRs after HRF deconvolution was similar to those before HRF deconvolution. The results were visualized with the BrainNet Viewer (http://www.nitrc.org/projects/bnv/).
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f2: The regional SSBRs evoked by LF and HF stimuli.The distribution of SSBRs after HRF deconvolution was similar to those before HRF deconvolution. The results were visualized with the BrainNet Viewer (http://www.nitrc.org/projects/bnv/).

Mentions: Figure 2 shows that SSBRs were evoked at 0.06–0.065 Hz and 0.1225–0.1275 Hz frequency bands in the left sensorimotor area (SA) and bilateral supplementary motor area (SMA) on both LF and HF conditions. Of note, no other regions had the similar effects with over 20 voxels at the 0.185–0.19 Hz frequency bands on the LF condition. Table 1 summarizes the visual cortex (VC), insula, ventral lateral frontal cortex (VLFC), inferior parietal lobe (IPL), posterior middle temporal gyrus (MTG) and inferior temporal gyrus (ITG) resonated on the HF condition at 0.1225–0.1275 Hz frequency band.


Steady-state BOLD response modulates low frequency neural oscillations.

Wang YF, Liu F, Long ZL, Duan XJ, Cui Q, Yan JH, Chen HF - Sci Rep (2014)

The regional SSBRs evoked by LF and HF stimuli.The distribution of SSBRs after HRF deconvolution was similar to those before HRF deconvolution. The results were visualized with the BrainNet Viewer (http://www.nitrc.org/projects/bnv/).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260215&req=5

f2: The regional SSBRs evoked by LF and HF stimuli.The distribution of SSBRs after HRF deconvolution was similar to those before HRF deconvolution. The results were visualized with the BrainNet Viewer (http://www.nitrc.org/projects/bnv/).
Mentions: Figure 2 shows that SSBRs were evoked at 0.06–0.065 Hz and 0.1225–0.1275 Hz frequency bands in the left sensorimotor area (SA) and bilateral supplementary motor area (SMA) on both LF and HF conditions. Of note, no other regions had the similar effects with over 20 voxels at the 0.185–0.19 Hz frequency bands on the LF condition. Table 1 summarizes the visual cortex (VC), insula, ventral lateral frontal cortex (VLFC), inferior parietal lobe (IPL), posterior middle temporal gyrus (MTG) and inferior temporal gyrus (ITG) resonated on the HF condition at 0.1225–0.1275 Hz frequency band.

Bottom Line: Specifically, the harmonic phenomenon of SSBR was task-related and independent of the neurovascular coupling.These findings suggested that the SSBRs represent non-linear neural oscillations but not brain activations.In comparison with the conventional general linear model, the SSBRs provide us novel insights into the non-linear brain activities, low frequency neural oscillations, and neuroplasticity of brain training and cognitive activities.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.

ABSTRACT
Neural oscillations are the intrinsic characteristics of brain activities. Traditional electrophysiological techniques (e.g., the steady-state evoked potential, SSEP) have provided important insights into the mechanisms of neural oscillations in the high frequency ranges (>1 Hz). However, the neural oscillations within the low frequency ranges (<1 Hz) and deep brain areas are rarely examined. Based on the advantages of the low frequency blood oxygen level dependent (BOLD) fluctuations, we expected that the steady-state BOLD responses (SSBRs) would be elicited and modulate low frequency neural oscillations. Twenty six participants completed a simple reaction time task with the constant stimuli frequencies of 0.0625 Hz and 0.125 Hz. Power analysis and hemodynamic response function deconvolution method were used to extract SSBRs and recover neural level signals. The SSEP-like waveforms were observed at the whole brain level and at several task-related brain regions. Specifically, the harmonic phenomenon of SSBR was task-related and independent of the neurovascular coupling. These findings suggested that the SSBRs represent non-linear neural oscillations but not brain activations. In comparison with the conventional general linear model, the SSBRs provide us novel insights into the non-linear brain activities, low frequency neural oscillations, and neuroplasticity of brain training and cognitive activities.

Show MeSH
Related in: MedlinePlus