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Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant.

Ling H, Ling H, de Silva R, Massey LA, Courtney R, Hondhamuni G, Bajaj N, Lowe J, Holton JL, Lees A, Revesz T - Neuropathol. Appl. Neurobiol. (2014)

Bottom Line: We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a 'cortical' PSP variant.PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups.A better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies.

View Article: PubMed Central - PubMed

Affiliation: Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK; Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK; Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, UK.

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A more severe microglial pathology in the corticospinal tract was identified in PSP-CBS when compared with PSP-RS (χ2; P = 0.035). A semi-quantitative grading scale was used to characterize the severity of microglial pathology; grade 0 = baseline microglial population, grade 1 = mild microglial pathology; grade 2 = moderate microglial pathology; grade 3 = severe microglial pathology.
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fig05: A more severe microglial pathology in the corticospinal tract was identified in PSP-CBS when compared with PSP-RS (χ2; P = 0.035). A semi-quantitative grading scale was used to characterize the severity of microglial pathology; grade 0 = baseline microglial population, grade 1 = mild microglial pathology; grade 2 = moderate microglial pathology; grade 3 = severe microglial pathology.

Mentions: There was a more severe microglial response in the CST in PSP-CBS, ranged from mild to severe, than in PSP-RS, in which CST involvement was very mild (χ2; P = 0.035) (Figure 5).


Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant.

Ling H, Ling H, de Silva R, Massey LA, Courtney R, Hondhamuni G, Bajaj N, Lowe J, Holton JL, Lees A, Revesz T - Neuropathol. Appl. Neurobiol. (2014)

A more severe microglial pathology in the corticospinal tract was identified in PSP-CBS when compared with PSP-RS (χ2; P = 0.035). A semi-quantitative grading scale was used to characterize the severity of microglial pathology; grade 0 = baseline microglial population, grade 1 = mild microglial pathology; grade 2 = moderate microglial pathology; grade 3 = severe microglial pathology.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260147&req=5

fig05: A more severe microglial pathology in the corticospinal tract was identified in PSP-CBS when compared with PSP-RS (χ2; P = 0.035). A semi-quantitative grading scale was used to characterize the severity of microglial pathology; grade 0 = baseline microglial population, grade 1 = mild microglial pathology; grade 2 = moderate microglial pathology; grade 3 = severe microglial pathology.
Mentions: There was a more severe microglial response in the CST in PSP-CBS, ranged from mild to severe, than in PSP-RS, in which CST involvement was very mild (χ2; P = 0.035) (Figure 5).

Bottom Line: We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a 'cortical' PSP variant.PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups.A better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies.

View Article: PubMed Central - PubMed

Affiliation: Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK; Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK; Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, UK.

Show MeSH
Related in: MedlinePlus