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Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant.

Ling H, Ling H, de Silva R, Massey LA, Courtney R, Hondhamuni G, Bajaj N, Lowe J, Holton JL, Lees A, Revesz T - Neuropathol. Appl. Neurobiol. (2014)

Bottom Line: We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a 'cortical' PSP variant.PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups.A better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies.

View Article: PubMed Central - PubMed

Affiliation: Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK; Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK; Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, UK.

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PSP-RS (B) has greater degree of neuronal loss in the ventrolateral (arrows) and dorsolateral substantia nigra than in PSP-CBS (A). Haematoxylin and eosin method, bar in panel B represents 1135 microns in both panels.
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fig04: PSP-RS (B) has greater degree of neuronal loss in the ventrolateral (arrows) and dorsolateral substantia nigra than in PSP-CBS (A). Haematoxylin and eosin method, bar in panel B represents 1135 microns in both panels.

Mentions: In the STN, the median semi-quantitative rating score for neuronal loss was moderate (grade 2) and there was no difference between the two groups (χ2; P ≥ 0.05). In the SN, neuronal loss was more severe in the dorsolateral (χ2; P = 0.033) and ventrolateral (χ2; P = 0.018) subregions in PSP-RS than in PSP-CBS (Figure 4).


Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant.

Ling H, Ling H, de Silva R, Massey LA, Courtney R, Hondhamuni G, Bajaj N, Lowe J, Holton JL, Lees A, Revesz T - Neuropathol. Appl. Neurobiol. (2014)

PSP-RS (B) has greater degree of neuronal loss in the ventrolateral (arrows) and dorsolateral substantia nigra than in PSP-CBS (A). Haematoxylin and eosin method, bar in panel B represents 1135 microns in both panels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260147&req=5

fig04: PSP-RS (B) has greater degree of neuronal loss in the ventrolateral (arrows) and dorsolateral substantia nigra than in PSP-CBS (A). Haematoxylin and eosin method, bar in panel B represents 1135 microns in both panels.
Mentions: In the STN, the median semi-quantitative rating score for neuronal loss was moderate (grade 2) and there was no difference between the two groups (χ2; P ≥ 0.05). In the SN, neuronal loss was more severe in the dorsolateral (χ2; P = 0.033) and ventrolateral (χ2; P = 0.018) subregions in PSP-RS than in PSP-CBS (Figure 4).

Bottom Line: We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a 'cortical' PSP variant.PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups.A better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies.

View Article: PubMed Central - PubMed

Affiliation: Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK; Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK; Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, UK.

Show MeSH
Related in: MedlinePlus