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Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant.

Ling H, Ling H, de Silva R, Massey LA, Courtney R, Hondhamuni G, Bajaj N, Lowe J, Holton JL, Lees A, Revesz T - Neuropathol. Appl. Neurobiol. (2014)

Bottom Line: We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a 'cortical' PSP variant.PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups.A better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies.

View Article: PubMed Central - PubMed

Affiliation: Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK; Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK; Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, UK.

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The median ‘total tau load’ between the PSP-CBS and PSP-RS groups are the same. However, the PSP-CBS group has greater median ‘cortical tau load’ and less ‘basal ganglia tau load’ than the PSP-RS group (Mann–Whitney U-Test). ‘Cortical tau load’ is the sum of regional tau load of posterior frontal grey matter, anterior frontal grey and white matter, temporal grey and white matter, parietal grey and white matter. ‘Basal ganglia tau load’ is the sum of regional tau load of caudate, putamen, globus pallidus and subthalamic nucleus. ‘Total tau load’ is the sum of regional tau load of all 15 brain regions. Error bars represent 95% confidence interval.
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fig03: The median ‘total tau load’ between the PSP-CBS and PSP-RS groups are the same. However, the PSP-CBS group has greater median ‘cortical tau load’ and less ‘basal ganglia tau load’ than the PSP-RS group (Mann–Whitney U-Test). ‘Cortical tau load’ is the sum of regional tau load of posterior frontal grey matter, anterior frontal grey and white matter, temporal grey and white matter, parietal grey and white matter. ‘Basal ganglia tau load’ is the sum of regional tau load of caudate, putamen, globus pallidus and subthalamic nucleus. ‘Total tau load’ is the sum of regional tau load of all 15 brain regions. Error bars represent 95% confidence interval.

Mentions: The presence of delayed initiation of horizontal saccades in PSP-CBS had a moderate correlation with an increased total parietal ‘tau load’ (Spearman's correlation coefficient = 0.59; P < 0.001). However, other cortical features such as cortical sensory loss, alien limb phenomenon or hemi-sensory neglect did not correlate with the parietal ‘tau load’ (P > 0.05) or other ‘regional tau load’.


Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant.

Ling H, Ling H, de Silva R, Massey LA, Courtney R, Hondhamuni G, Bajaj N, Lowe J, Holton JL, Lees A, Revesz T - Neuropathol. Appl. Neurobiol. (2014)

The median ‘total tau load’ between the PSP-CBS and PSP-RS groups are the same. However, the PSP-CBS group has greater median ‘cortical tau load’ and less ‘basal ganglia tau load’ than the PSP-RS group (Mann–Whitney U-Test). ‘Cortical tau load’ is the sum of regional tau load of posterior frontal grey matter, anterior frontal grey and white matter, temporal grey and white matter, parietal grey and white matter. ‘Basal ganglia tau load’ is the sum of regional tau load of caudate, putamen, globus pallidus and subthalamic nucleus. ‘Total tau load’ is the sum of regional tau load of all 15 brain regions. Error bars represent 95% confidence interval.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260147&req=5

fig03: The median ‘total tau load’ between the PSP-CBS and PSP-RS groups are the same. However, the PSP-CBS group has greater median ‘cortical tau load’ and less ‘basal ganglia tau load’ than the PSP-RS group (Mann–Whitney U-Test). ‘Cortical tau load’ is the sum of regional tau load of posterior frontal grey matter, anterior frontal grey and white matter, temporal grey and white matter, parietal grey and white matter. ‘Basal ganglia tau load’ is the sum of regional tau load of caudate, putamen, globus pallidus and subthalamic nucleus. ‘Total tau load’ is the sum of regional tau load of all 15 brain regions. Error bars represent 95% confidence interval.
Mentions: The presence of delayed initiation of horizontal saccades in PSP-CBS had a moderate correlation with an increased total parietal ‘tau load’ (Spearman's correlation coefficient = 0.59; P < 0.001). However, other cortical features such as cortical sensory loss, alien limb phenomenon or hemi-sensory neglect did not correlate with the parietal ‘tau load’ (P > 0.05) or other ‘regional tau load’.

Bottom Line: We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a 'cortical' PSP variant.PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups.A better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies.

View Article: PubMed Central - PubMed

Affiliation: Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK; Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK; Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, UK.

Show MeSH
Related in: MedlinePlus