Characterization of a population of neural progenitor cells in the infant hippocampus.
Bottom Line: Previous work suggested that these cells were microglia and that their presence was associated with chronic illness and sudden infant death syndrome.The rod cells were consistently negative for the microglial markers CD45, CD68 and HLA-DR.These findings advance our understanding of postnatal neurogenesis in the human hippocampus in health and disease and are of diagnostic importance, allowing reactive microglia to be distinguished from the normal population of neural progenitors.
Affiliation: Neural Development Unit, Birth Defects Research Centre, UCL Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.Show MeSH
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Mentions: The rod cells in the initial cohort of five cases were uniformly negative for the microglialmarkers CD68, CD45 and HLA-DR (Figure 1). In thelarger cohort of 40 cases, all had rod cells present but only six cases of eSUDI and one of uSUDIhad significant numbers of infiltrating CD68-positive microglia. However, even in cases where therewas a florid CD68-positive microglial response (e.g. established hypoxic/ischaemic injury), aconsistent population of rod cells was present that were negative for CD68. CD68 did not stain therod cells of the PML in any of the remaining cases.
Affiliation: Neural Development Unit, Birth Defects Research Centre, UCL Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.