Modifications of glucocorticoid receptors mRNA expression in the hypothalamic-pituitary-adrenal axis in response to early-life stress in female Japanese quail.
Bottom Line: The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback.This reduced feedback efficiency usually results from a reduced level of the glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR) within the HPA axis.Postnatal stress resulted in a reduced MR expression in the hippocampus.
Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.Show MeSH
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Mentions: In the hypothalamus, relative MR mRNA expression was increased following exposure to prenatal stress (χ² = 4.53, d.f. = 1,30, P = 0.033) (Fig. 4), although there were no effects of postnatal treatments or any interaction between the two stages (Table 1). There were no main effects of either early-life treatment on GR expression, although there was an effect of the interactions between both treatments (χ² = 5.02, d.f. = 1,31, P = 0.025). GR expression was higher in individuals only exposed to prenatal stress (BC) than in individuals exposed to none (CC) or both stresses (BF−) (Z > 2.05, P < 0.041) (Fig. 5).
Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.