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Modifications of glucocorticoid receptors mRNA expression in the hypothalamic-pituitary-adrenal axis in response to early-life stress in female Japanese quail.

Zimmer C, Spencer KA - J. Neuroendocrinol. (2014)

Bottom Line: The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback.This reduced feedback efficiency usually results from a reduced level of the glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR) within the HPA axis.Postnatal stress resulted in a reduced MR expression in the hippocampus.

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Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.

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Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hypothalamus of prenatal control (C) and prenatally stressed (B) quail. *Statistically significant difference.
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fig04: Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hypothalamus of prenatal control (C) and prenatally stressed (B) quail. *Statistically significant difference.

Mentions: In the hypothalamus, relative MR mRNA expression was increased following exposure to prenatal stress (χ² = 4.53, d.f. = 1,30, P = 0.033) (Fig. 4), although there were no effects of postnatal treatments or any interaction between the two stages (Table 1). There were no main effects of either early-life treatment on GR expression, although there was an effect of the interactions between both treatments (χ² = 5.02, d.f. = 1,31, P = 0.025). GR expression was higher in individuals only exposed to prenatal stress (BC) than in individuals exposed to none (CC) or both stresses (BF−) (Z > 2.05, P < 0.041) (Fig. 5).


Modifications of glucocorticoid receptors mRNA expression in the hypothalamic-pituitary-adrenal axis in response to early-life stress in female Japanese quail.

Zimmer C, Spencer KA - J. Neuroendocrinol. (2014)

Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hypothalamus of prenatal control (C) and prenatally stressed (B) quail. *Statistically significant difference.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260142&req=5

fig04: Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hypothalamus of prenatal control (C) and prenatally stressed (B) quail. *Statistically significant difference.
Mentions: In the hypothalamus, relative MR mRNA expression was increased following exposure to prenatal stress (χ² = 4.53, d.f. = 1,30, P = 0.033) (Fig. 4), although there were no effects of postnatal treatments or any interaction between the two stages (Table 1). There were no main effects of either early-life treatment on GR expression, although there was an effect of the interactions between both treatments (χ² = 5.02, d.f. = 1,31, P = 0.025). GR expression was higher in individuals only exposed to prenatal stress (BC) than in individuals exposed to none (CC) or both stresses (BF−) (Z > 2.05, P < 0.041) (Fig. 5).

Bottom Line: The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback.This reduced feedback efficiency usually results from a reduced level of the glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR) within the HPA axis.Postnatal stress resulted in a reduced MR expression in the hippocampus.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.

Show MeSH
Related in: MedlinePlus