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Modifications of glucocorticoid receptors mRNA expression in the hypothalamic-pituitary-adrenal axis in response to early-life stress in female Japanese quail.

Zimmer C, Spencer KA - J. Neuroendocrinol. (2014)

Bottom Line: The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback.This reduced feedback efficiency usually results from a reduced level of the glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR) within the HPA axis.Postnatal stress resulted in a reduced MR expression in the hippocampus.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.

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Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hippocampus of quail in the four treatment groups: pre-hatching and post-hatching control (CC), pre-hatching control and post-hatching unpredictable food availability (CF−), pre-hatching corticosterone-treated and post-hatching control (BC) and both treatments (BF−). *Statistically significant difference.
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fig02: Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hippocampus of quail in the four treatment groups: pre-hatching and post-hatching control (CC), pre-hatching control and post-hatching unpredictable food availability (CF−), pre-hatching corticosterone-treated and post-hatching control (BC) and both treatments (BF−). *Statistically significant difference.

Mentions: Mineralocorticoid receptor relative mRNA expression in the hippocampus was significantly reduced in postnatally stressed compared to postnatal control quail (χ² = 6.11, d.f. = 1,23, P = 0.013). Moreover, MR relative expression was significantly influenced by the interaction between both early-life treatments (prenatal treatment × postnatal treatment: χ2 = 4.10 d.f. = 1,23, P = 0.0428). Post-hoc comparisons were not significant; however, it appears that MR expression was the highest in control individuals exposed to none of the stresses (CC) compared to individuals exposed to one or both early stresses (Fig. 2). GR mRNA relative expression in the hippocampus was not affected by any of early-life stresses (Table 1). The GR:MR ratio was significantly affected by early-life stress, with a lower ratio in prenatal control quail compared to prenatally stressed individuals (χ² = 9.60, d.f. = 1,27, P = 0.002) (Fig. 3).


Modifications of glucocorticoid receptors mRNA expression in the hypothalamic-pituitary-adrenal axis in response to early-life stress in female Japanese quail.

Zimmer C, Spencer KA - J. Neuroendocrinol. (2014)

Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hippocampus of quail in the four treatment groups: pre-hatching and post-hatching control (CC), pre-hatching control and post-hatching unpredictable food availability (CF−), pre-hatching corticosterone-treated and post-hatching control (BC) and both treatments (BF−). *Statistically significant difference.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260142&req=5

fig02: Mean ± SEM relative expression of the mineralocorticoid receptor (MR) in the hippocampus of quail in the four treatment groups: pre-hatching and post-hatching control (CC), pre-hatching control and post-hatching unpredictable food availability (CF−), pre-hatching corticosterone-treated and post-hatching control (BC) and both treatments (BF−). *Statistically significant difference.
Mentions: Mineralocorticoid receptor relative mRNA expression in the hippocampus was significantly reduced in postnatally stressed compared to postnatal control quail (χ² = 6.11, d.f. = 1,23, P = 0.013). Moreover, MR relative expression was significantly influenced by the interaction between both early-life treatments (prenatal treatment × postnatal treatment: χ2 = 4.10 d.f. = 1,23, P = 0.0428). Post-hoc comparisons were not significant; however, it appears that MR expression was the highest in control individuals exposed to none of the stresses (CC) compared to individuals exposed to one or both early stresses (Fig. 2). GR mRNA relative expression in the hippocampus was not affected by any of early-life stresses (Table 1). The GR:MR ratio was significantly affected by early-life stress, with a lower ratio in prenatal control quail compared to prenatally stressed individuals (χ² = 9.60, d.f. = 1,27, P = 0.002) (Fig. 3).

Bottom Line: The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback.This reduced feedback efficiency usually results from a reduced level of the glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR) within the HPA axis.Postnatal stress resulted in a reduced MR expression in the hippocampus.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.

Show MeSH
Related in: MedlinePlus