Modifications of glucocorticoid receptors mRNA expression in the hypothalamic-pituitary-adrenal axis in response to early-life stress in female Japanese quail.
Bottom Line: The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback.This reduced feedback efficiency usually results from a reduced level of the glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR) within the HPA axis.Postnatal stress resulted in a reduced MR expression in the hippocampus.
Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.Show MeSH
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Mentions: The expression of both receptors (MR and GR) was different between the three HPA axis regions (χ² = 15.80, d.f. = 1,189, P = 0.0004) (Fig. 1), with higher expression in the pituitary gland compared to both other tissues (Z> 3.39, P < 0.002). The expression of both receptors was different within each tissue (receptor × tissue: χ² = 11.71,, d.f. = 1,189, P = 0.003) (Fig. 1). In the hippocampus, MR was more highly expressed than GR (Z = 2.58, P = 0.01). In the hypothalamus, GR was highly expressed compared to MR (Z = 2.01, P = 0.04). Finally, in the pituitary gland, MR and GR relative expression did not differ (Z = 1.04, P = 0.30).
Affiliation: School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.