Pregnancy and helminth infections.
Bottom Line: It has been proposed that helminth infection may be particularly detrimental during pregnancy, through adverse effects on maternal anaemia and on birth outcomes, and that anthelminthic treatment during pregnancy will therefore be particularly beneficial.There is evidence that this may impact, long-term, upon responses to helminth and nonhelminth antigens, and to allergens.Exposure to helminths in utero may also have nonspecific effects that may modify the offspring's susceptibility to diseases mediated by inflammation, including metabolic disorders.
Affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.Show MeSH
Related in: MedlinePlus
Mentions: The mechanisms by which maternal helminth infection can influence outcomes in the foetus are not known. Investigation of these mechanisms might shed important light on the development on the infant immune response and inform the development of possible interventions for the primary prevention of immunologically mediated conditions, such as allergy 81. Some possible mechanisms are summarized in Figure 1 and discussed below.
Affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.