Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.
Bottom Line: The deep fibular nerve was stimulated transcutaneously to activate the tibialis anterior muscle and produce dorsiflexion of the foot.The force-frequency relationship of tibialis anterior dorsiflexion was assessed after dosing.The data confirm that tirasemtiv amplifies the response of skeletal muscle to nerve input in humans.
Affiliation: Research and Early Development, Cytokinetics, Inc., 280 East Grand Avenue, South San Francisco, California, 94080-4808, USA.Show MeSH
Related in: MedlinePlus
Mentions: Tirasemtiv increased the placebo-corrected summed percent change from baseline of peak force (ΣF) in a dose-dependent manner (Fig. 2A). Statistically significant increases in force relative to pre-dose baseline values when compared with placebo occurred at doses of 500 and 1000 mg at all time-points and for all comparisons between 250 and 1000 mg (P < 0.05). Although comparisons of intermediate dose steps (i.e., 250–500 or 500–1000 mg) did not generally reach statistical significance, the overall dose dependence was strongly significant statistically at all time-points (P < 0.002). Forces increased between the 1- and 3-hour time-points commensurate with the rise in tirasemtiv plasma concentrations; the increases in force were maintained out to the last time-point measured at 7 hours, as were tirasemtiv plasma concentrations.
Affiliation: Research and Early Development, Cytokinetics, Inc., 280 East Grand Avenue, South San Francisco, California, 94080-4808, USA.