Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.
Bottom Line: The deep fibular nerve was stimulated transcutaneously to activate the tibialis anterior muscle and produce dorsiflexion of the foot.The data confirm that tirasemtiv amplifies the response of skeletal muscle to nerve input in humans.This outcome provides support for further studies of tirasemtiv as a potential therapy in conditions marked by diminished neuromuscular input.
Affiliation: Research and Early Development, Cytokinetics, Inc., 280 East Grand Avenue, South San Francisco, California, 94080-4808, USA.Show MeSH
Mentions: An example of forces elicited with stimulus frequencies from 5 to 50 Hz and the resulting force–frequency relationship from a subject after placebo treatment is shown in Figure 1. Stimulation frequencies ranged from 5 Hz, where there was little or no summation of individual muscle twitches, up to 50 Hz, where the maximum force was observed. The force–frequency response was steepest around 10 Hz, which is close to the minimal discharge rate of single motor units in this muscle.8,11,12
Affiliation: Research and Early Development, Cytokinetics, Inc., 280 East Grand Avenue, South San Francisco, California, 94080-4808, USA.