Risk of acute liver injury associated with the use of moxifloxacin and other oral antimicrobials: a retrospective, population-based cohort study.
Bottom Line: Levofloxacin had the highest relative risk for current single use (3.2, 95% CI 1.8-5.8).Relative risks were also elevated for amoxicillin-clavulanic acid (2.5, 95% CI 1.3-5.0), doxycycline (2.5, 95% CI 1.2-5.2), moxifloxacin (2.3, 95% CI 1.1-4.7), and amoxicillin (2.3, 95% CI 1.1-4.7).The results support a comparatively high adjusted relative risk of liver injury among patients exposed concurrently to multiple antimicrobials and modest elevations in the risk for several antimicrobials used alone; however, we found little evidence of any strong effect of commonly used antimicrobials on the risk of liver injury.
Affiliation: Epidemiology, RTI Health Solutions, Waltham, Massachusetts.Show MeSH
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Mentions: In screening, we found 715 potential cases of liver injury. Case validation results are shown in Figure1. Of the 420 cases with adequate records, 312 were valid and 108 were not cases; 295 were of uncertain status (as defined earlier).
Affiliation: Epidemiology, RTI Health Solutions, Waltham, Massachusetts.