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Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study.

Sofi F, Whittaker A, Cesari F, Gori AM, Fiorillo C, Becatti M, Marotti I, Dinelli G, Casini A, Abbate R, Gensini GF, Benedettelli S - Eur J Clin Nutr (2013)

Bottom Line: At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose.Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%).Circulating levels of key pro-inflammatory cytokines (interleukin (IL)-6, IL-12, tumour necrosis factor-α and vascular endothelial growth factor) were significantly reduced after the consumption of Kamut products.

View Article: PubMed Central - PubMed

Affiliation: Agency of Nutrition, Careggi University Hospital, Florence, Italy. francescosofi@gmail.com

ABSTRACT

Background/objectives: Khorasan wheat (Kamut) is an ancient grain with widely acclaimed beneficial effects on human health. The objective was to characterise Kamut and to examine the effect of a replacement diet with their products on cardiovascular risk parameters.

Subjects/methods: We conducted a randomized, single-blinded cross-over trial with two intervention phases on 22 healthy subjects (14 females; 8 males). The participants were assigned to consume products (bread, pasta and crackers) made either from Kamut or control semi-whole-grain wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase.

Results: At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose. Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%). The replacement diet with Kamut products also resulted in a significant increase of serum potassium and magnesium. Circulating levels of key pro-inflammatory cytokines (interleukin (IL)-6, IL-12, tumour necrosis factor-α and vascular endothelial growth factor) were significantly reduced after the consumption of Kamut products.

Conclusions: The present results suggest that a replacement diet with Kamut products could be effective in reducing metabolic risk factors, markers of both oxidative stress and inflammatory status.

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Mean percentage of change for selected inflammatory cytokines.
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fig2: Mean percentage of change for selected inflammatory cytokines.

Mentions: After the period of dietary replacement with Kamut products, a significant reduction in the circulating levels of some pro-inflammatory cytokines such as interleukin (IL)-6 (−23.6%), IL-12 (−28.1%), monocyte chemotactic protein-1 (−17%), macrophage inflammatory protein-1β (−14.7%), tumour necrosis factor-α (−34.6%) and vascular endothelial growth factor (−10.5%) was observed (Table 5). In contrast, after the period of intervention with the control products, the only significant reductions reported were for monocyte chemotactic protein-1 (−16.9%) and macrophage inflammatory protein-1β (−18.7%) levels (Figure 2).


Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study.

Sofi F, Whittaker A, Cesari F, Gori AM, Fiorillo C, Becatti M, Marotti I, Dinelli G, Casini A, Abbate R, Gensini GF, Benedettelli S - Eur J Clin Nutr (2013)

Mean percentage of change for selected inflammatory cytokines.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260112&req=5

fig2: Mean percentage of change for selected inflammatory cytokines.
Mentions: After the period of dietary replacement with Kamut products, a significant reduction in the circulating levels of some pro-inflammatory cytokines such as interleukin (IL)-6 (−23.6%), IL-12 (−28.1%), monocyte chemotactic protein-1 (−17%), macrophage inflammatory protein-1β (−14.7%), tumour necrosis factor-α (−34.6%) and vascular endothelial growth factor (−10.5%) was observed (Table 5). In contrast, after the period of intervention with the control products, the only significant reductions reported were for monocyte chemotactic protein-1 (−16.9%) and macrophage inflammatory protein-1β (−18.7%) levels (Figure 2).

Bottom Line: At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose.Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%).Circulating levels of key pro-inflammatory cytokines (interleukin (IL)-6, IL-12, tumour necrosis factor-α and vascular endothelial growth factor) were significantly reduced after the consumption of Kamut products.

View Article: PubMed Central - PubMed

Affiliation: Agency of Nutrition, Careggi University Hospital, Florence, Italy. francescosofi@gmail.com

ABSTRACT

Background/objectives: Khorasan wheat (Kamut) is an ancient grain with widely acclaimed beneficial effects on human health. The objective was to characterise Kamut and to examine the effect of a replacement diet with their products on cardiovascular risk parameters.

Subjects/methods: We conducted a randomized, single-blinded cross-over trial with two intervention phases on 22 healthy subjects (14 females; 8 males). The participants were assigned to consume products (bread, pasta and crackers) made either from Kamut or control semi-whole-grain wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase.

Results: At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose. Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%). The replacement diet with Kamut products also resulted in a significant increase of serum potassium and magnesium. Circulating levels of key pro-inflammatory cytokines (interleukin (IL)-6, IL-12, tumour necrosis factor-α and vascular endothelial growth factor) were significantly reduced after the consumption of Kamut products.

Conclusions: The present results suggest that a replacement diet with Kamut products could be effective in reducing metabolic risk factors, markers of both oxidative stress and inflammatory status.

Show MeSH