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Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study.

Sofi F, Whittaker A, Cesari F, Gori AM, Fiorillo C, Becatti M, Marotti I, Dinelli G, Casini A, Abbate R, Gensini GF, Benedettelli S - Eur J Clin Nutr (2013)

Bottom Line: Khorasan wheat (Kamut) is an ancient grain with widely acclaimed beneficial effects on human health.At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose.Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%).

View Article: PubMed Central - PubMed

Affiliation: Agency of Nutrition, Careggi University Hospital, Florence, Italy. francescosofi@gmail.com

ABSTRACT

Background/objectives: Khorasan wheat (Kamut) is an ancient grain with widely acclaimed beneficial effects on human health. The objective was to characterise Kamut and to examine the effect of a replacement diet with their products on cardiovascular risk parameters.

Subjects/methods: We conducted a randomized, single-blinded cross-over trial with two intervention phases on 22 healthy subjects (14 females; 8 males). The participants were assigned to consume products (bread, pasta and crackers) made either from Kamut or control semi-whole-grain wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase.

Results: At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose. Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%). The replacement diet with Kamut products also resulted in a significant increase of serum potassium and magnesium. Circulating levels of key pro-inflammatory cytokines (interleukin (IL)-6, IL-12, tumour necrosis factor-α and vascular endothelial growth factor) were significantly reduced after the consumption of Kamut products.

Conclusions: The present results suggest that a replacement diet with Kamut products could be effective in reducing metabolic risk factors, markers of both oxidative stress and inflammatory status.

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Mean percentage of change for selected metabolic parameters and minerals.
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fig1: Mean percentage of change for selected metabolic parameters and minerals.

Mentions: To test the possible effects of a replacement diet with Kamut products on the parameters investigated, a general linear model for repeated measurements, adjusted for age, gender, smoking habit, hypertension and physical activity was performed. In Table 3, adjusted values for BMI and all the variables investigated before and after the two dietary interventions were reported. During the phase of dietary replacement with Kamut products, participants experienced a significant amelioration of some parameters such as blood glucose, alanine aminotransferase, total cholesterol and low-density lipoprotein cholesterol. Indeed, total cholesterol decreased significantly by 4%, with a mean reduction of 8.46 mg/dl and low-density lipoprotein cholesterol by 7.8% with a mean reduction of 9.82 mg/dl, respectively. In contrast, no significant changes during the phase of dietary replacement with control wheat products were reported (Figure 1).


Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study.

Sofi F, Whittaker A, Cesari F, Gori AM, Fiorillo C, Becatti M, Marotti I, Dinelli G, Casini A, Abbate R, Gensini GF, Benedettelli S - Eur J Clin Nutr (2013)

Mean percentage of change for selected metabolic parameters and minerals.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260112&req=5

fig1: Mean percentage of change for selected metabolic parameters and minerals.
Mentions: To test the possible effects of a replacement diet with Kamut products on the parameters investigated, a general linear model for repeated measurements, adjusted for age, gender, smoking habit, hypertension and physical activity was performed. In Table 3, adjusted values for BMI and all the variables investigated before and after the two dietary interventions were reported. During the phase of dietary replacement with Kamut products, participants experienced a significant amelioration of some parameters such as blood glucose, alanine aminotransferase, total cholesterol and low-density lipoprotein cholesterol. Indeed, total cholesterol decreased significantly by 4%, with a mean reduction of 8.46 mg/dl and low-density lipoprotein cholesterol by 7.8% with a mean reduction of 9.82 mg/dl, respectively. In contrast, no significant changes during the phase of dietary replacement with control wheat products were reported (Figure 1).

Bottom Line: Khorasan wheat (Kamut) is an ancient grain with widely acclaimed beneficial effects on human health.At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose.Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%).

View Article: PubMed Central - PubMed

Affiliation: Agency of Nutrition, Careggi University Hospital, Florence, Italy. francescosofi@gmail.com

ABSTRACT

Background/objectives: Khorasan wheat (Kamut) is an ancient grain with widely acclaimed beneficial effects on human health. The objective was to characterise Kamut and to examine the effect of a replacement diet with their products on cardiovascular risk parameters.

Subjects/methods: We conducted a randomized, single-blinded cross-over trial with two intervention phases on 22 healthy subjects (14 females; 8 males). The participants were assigned to consume products (bread, pasta and crackers) made either from Kamut or control semi-whole-grain wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase.

Results: At a general linear model for repeated measurements adjusted for several confounders, consumption of Kamut products showed a significant reduction of metabolic risk factors such as total cholesterol (mean reduction: -8.46 mg/dl; -4%), low-density lipoprotein cholesterol (-9.82 mg/dl; -7.8%) and blood glucose. Similarly, redox status was significantly improved only after the Kamut intervention phase, as measured by a reduction in both thiobarbituric acid reactive substances (-0.17 nmol/ml; -21.5%;) and carbonyl levels (-0.16 nmol/ml; -17.6%). The replacement diet with Kamut products also resulted in a significant increase of serum potassium and magnesium. Circulating levels of key pro-inflammatory cytokines (interleukin (IL)-6, IL-12, tumour necrosis factor-α and vascular endothelial growth factor) were significantly reduced after the consumption of Kamut products.

Conclusions: The present results suggest that a replacement diet with Kamut products could be effective in reducing metabolic risk factors, markers of both oxidative stress and inflammatory status.

Show MeSH
Related in: MedlinePlus