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Endoscopic Submucosal Dissection Using a Novel Versatile Knife: An Animal Feasibility Study (with Video).

Kwon CI, Kim G, Chung IK, Kim WH, Ko KH, Hong SP, Jeong S, Lee DH - Clin Endosc (2014)

Bottom Line: A total of 18 specimens were dissected by ESD safely and easily (nine specimens using the new versatile knife; nine specimens by mixing conventional knives).The rate of adverse events and histological quality did not statistically differ between the modalities.ESD with a versatile knife appeared to be an easy, safe, and technically efficient method.

View Article: PubMed Central - PubMed

Affiliation: Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

ABSTRACT

Background/aims: In order to reduce the procedure time and the number of accessory changes during endoscopic submucosal dissection (ESD), we developed a novel versatile knife, which has the combined advantages of several conventional knives. The aim of this study was to compare the efficacy, safety, and histological quality of ESD performed using this novel versatile knife and a combination of several conventional knives.

Methods: This was an in vivo animal study comparing two different modalities of ESD in mini-pigs. Completion time of each resection was documented, and the resected specimens were retrieved and evaluated for completeness. To assess the quality control of the procedures and adverse events, detailed histopathological examinations were performed.

Results: A total of 18 specimens were dissected by ESD safely and easily (nine specimens using the new versatile knife; nine specimens by mixing conventional knives). All resections were completed as en bloc resections. There was no significant difference in procedure time between the 2 modalities (456 seconds vs. 355 seconds, p=0.258) and cutting speed (1.983 mm(2)/sec vs. 1.57 mm(2)/sec, p=1.000). The rate of adverse events and histological quality did not statistically differ between the modalities.

Conclusions: ESD with a versatile knife appeared to be an easy, safe, and technically efficient method.

No MeSH data available.


Tissues from resected specimens pinned on a rubber board after formalin fixation. (Inset) Resected specimens just after the procedure.
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Figure 4: Tissues from resected specimens pinned on a rubber board after formalin fixation. (Inset) Resected specimens just after the procedure.

Mentions: Both pigs were alive during the 18 hours before euthanasia and necropsy showed no complicated findings. The resected stomachs were incised along the lesser curvature to expose the interior, where no adverse event was found (Fig. 3). All endoscopically resected specimens were rapidly retrieved after the ESD, and pinned onto a rubber board to measure the largest diameter and extent (Fig. 4). The tissues were then placed and fixed in 10% formalin for histological assessment. Hematoxylin and eosin staining was used.


Endoscopic Submucosal Dissection Using a Novel Versatile Knife: An Animal Feasibility Study (with Video).

Kwon CI, Kim G, Chung IK, Kim WH, Ko KH, Hong SP, Jeong S, Lee DH - Clin Endosc (2014)

Tissues from resected specimens pinned on a rubber board after formalin fixation. (Inset) Resected specimens just after the procedure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4260103&req=5

Figure 4: Tissues from resected specimens pinned on a rubber board after formalin fixation. (Inset) Resected specimens just after the procedure.
Mentions: Both pigs were alive during the 18 hours before euthanasia and necropsy showed no complicated findings. The resected stomachs were incised along the lesser curvature to expose the interior, where no adverse event was found (Fig. 3). All endoscopically resected specimens were rapidly retrieved after the ESD, and pinned onto a rubber board to measure the largest diameter and extent (Fig. 4). The tissues were then placed and fixed in 10% formalin for histological assessment. Hematoxylin and eosin staining was used.

Bottom Line: A total of 18 specimens were dissected by ESD safely and easily (nine specimens using the new versatile knife; nine specimens by mixing conventional knives).The rate of adverse events and histological quality did not statistically differ between the modalities.ESD with a versatile knife appeared to be an easy, safe, and technically efficient method.

View Article: PubMed Central - PubMed

Affiliation: Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

ABSTRACT

Background/aims: In order to reduce the procedure time and the number of accessory changes during endoscopic submucosal dissection (ESD), we developed a novel versatile knife, which has the combined advantages of several conventional knives. The aim of this study was to compare the efficacy, safety, and histological quality of ESD performed using this novel versatile knife and a combination of several conventional knives.

Methods: This was an in vivo animal study comparing two different modalities of ESD in mini-pigs. Completion time of each resection was documented, and the resected specimens were retrieved and evaluated for completeness. To assess the quality control of the procedures and adverse events, detailed histopathological examinations were performed.

Results: A total of 18 specimens were dissected by ESD safely and easily (nine specimens using the new versatile knife; nine specimens by mixing conventional knives). All resections were completed as en bloc resections. There was no significant difference in procedure time between the 2 modalities (456 seconds vs. 355 seconds, p=0.258) and cutting speed (1.983 mm(2)/sec vs. 1.57 mm(2)/sec, p=1.000). The rate of adverse events and histological quality did not statistically differ between the modalities.

Conclusions: ESD with a versatile knife appeared to be an easy, safe, and technically efficient method.

No MeSH data available.