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Equine influenza A(H3N8) virus infection in cats.

Su S, Wang L, Fu X, He S, Hong M, Zhou P, Lai A, Gray G, Li S - Emerging Infect. Dis. (2014)

Bottom Line: Interspecies transmission of equine influenza A(H3N8) virus has resulted in establishment of a canine influenza virus.To determine if something similar could happen with cats, we experimentally infected 14 cats with the equine influenza A(H3N8) virus.All showed clinical signs, shed virus, and transmitted the virus to a contact cohort.

View Article: PubMed Central - PubMed

ABSTRACT
Interspecies transmission of equine influenza A(H3N8) virus has resulted in establishment of a canine influenza virus. To determine if something similar could happen with cats, we experimentally infected 14 cats with the equine influenza A(H3N8) virus. All showed clinical signs, shed virus, and transmitted the virus to a contact cohort.

No MeSH data available.


Related in: MedlinePlus

Results of virus titration and hemagglutination-inhibition assay for the cohort of cats inoculated with equine influenza A(H3N8) virus and the contact cohort. Virus shedding was titrated in MDCK cells. Virus titer is shown as log10 median tissue culture infective dose (TCID50) (solid line and circles, inoculated cohort; dashed line and triangles, contact cohort). Hemagglutination-inhibition assay of serum samples was conducted by using 1% horse erythrocytes (black bars, inoculated; white bars, contact cohort). Error bars indicate SEM.
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Figure 1: Results of virus titration and hemagglutination-inhibition assay for the cohort of cats inoculated with equine influenza A(H3N8) virus and the contact cohort. Virus shedding was titrated in MDCK cells. Virus titer is shown as log10 median tissue culture infective dose (TCID50) (solid line and circles, inoculated cohort; dashed line and triangles, contact cohort). Hemagglutination-inhibition assay of serum samples was conducted by using 1% horse erythrocytes (black bars, inoculated; white bars, contact cohort). Error bars indicate SEM.

Mentions: The cats were susceptible to EIV infection; they showed overt clinical signs, virus shedding, and corresponding histopathologic changes in trachea and lung. Infected cats transmitted the virus to cats in the contact cohort. Overt clinical signs characteristic of acute influenza infection developed in inoculated cats during postinfection days 2–9 (peaking at day 4) and in contact cohort cats during days 4–9 (peaking at day 5); however, average clinical scores were lower for cats in the contact cohort than in the inoculated cohort (Table). Virus shedding was detected for cats in the inoculated group on days 2–5 and in the contact cohort on days 5–6 (Figure 1). This shift of virus shedding correlated with the shift in clinical signs, suggesting that the cohort group was infected by the virus shed from inoculated cats. Likewise, an antibody response was detected for cats in both groups, again 2–3 days later for the contact cohort.


Equine influenza A(H3N8) virus infection in cats.

Su S, Wang L, Fu X, He S, Hong M, Zhou P, Lai A, Gray G, Li S - Emerging Infect. Dis. (2014)

Results of virus titration and hemagglutination-inhibition assay for the cohort of cats inoculated with equine influenza A(H3N8) virus and the contact cohort. Virus shedding was titrated in MDCK cells. Virus titer is shown as log10 median tissue culture infective dose (TCID50) (solid line and circles, inoculated cohort; dashed line and triangles, contact cohort). Hemagglutination-inhibition assay of serum samples was conducted by using 1% horse erythrocytes (black bars, inoculated; white bars, contact cohort). Error bars indicate SEM.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4257791&req=5

Figure 1: Results of virus titration and hemagglutination-inhibition assay for the cohort of cats inoculated with equine influenza A(H3N8) virus and the contact cohort. Virus shedding was titrated in MDCK cells. Virus titer is shown as log10 median tissue culture infective dose (TCID50) (solid line and circles, inoculated cohort; dashed line and triangles, contact cohort). Hemagglutination-inhibition assay of serum samples was conducted by using 1% horse erythrocytes (black bars, inoculated; white bars, contact cohort). Error bars indicate SEM.
Mentions: The cats were susceptible to EIV infection; they showed overt clinical signs, virus shedding, and corresponding histopathologic changes in trachea and lung. Infected cats transmitted the virus to cats in the contact cohort. Overt clinical signs characteristic of acute influenza infection developed in inoculated cats during postinfection days 2–9 (peaking at day 4) and in contact cohort cats during days 4–9 (peaking at day 5); however, average clinical scores were lower for cats in the contact cohort than in the inoculated cohort (Table). Virus shedding was detected for cats in the inoculated group on days 2–5 and in the contact cohort on days 5–6 (Figure 1). This shift of virus shedding correlated with the shift in clinical signs, suggesting that the cohort group was infected by the virus shed from inoculated cats. Likewise, an antibody response was detected for cats in both groups, again 2–3 days later for the contact cohort.

Bottom Line: Interspecies transmission of equine influenza A(H3N8) virus has resulted in establishment of a canine influenza virus.To determine if something similar could happen with cats, we experimentally infected 14 cats with the equine influenza A(H3N8) virus.All showed clinical signs, shed virus, and transmitted the virus to a contact cohort.

View Article: PubMed Central - PubMed

ABSTRACT
Interspecies transmission of equine influenza A(H3N8) virus has resulted in establishment of a canine influenza virus. To determine if something similar could happen with cats, we experimentally infected 14 cats with the equine influenza A(H3N8) virus. All showed clinical signs, shed virus, and transmitted the virus to a contact cohort.

No MeSH data available.


Related in: MedlinePlus